2. Immunology/Inflammation
  3. Transmembrane Glycoprotein Toll-like Receptor (TLR)
  4. ABB071

ABB071 is a humanized anti-CD180 monoclonal antibody. ABB071 can down-regulate the highly expressed TLR7 and IRF5 genes in systemic lupus erythematosus and induce the expression of PNPT1 and DNASE1L3 genes. ABB071 can inhibit the expression of genes related to the type I interferon pathway as well as interferon-stimulated genes (ISGs). ABB071 has anti-inflammatory activity and can reduce the levels of inflammatory cytokines. ABB071 can be used for research on systemic lupus erythematosus and psoriasis.

For research use only. We do not sell to patients.

ABB071

ABB071 Chemical Structure

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ABB071 Related Antibodies

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Description

ABB071 is a humanized anti-CD180 monoclonal antibody. ABB071 can down-regulate the highly expressed TLR7 and IRF5 genes in systemic lupus erythematosus and induce the expression of PNPT1 and DNASE1L3 genes. ABB071 can inhibit the expression of genes related to the type I interferon pathway as well as interferon-stimulated genes (ISGs). ABB071 has anti-inflammatory activity and can reduce the levels of inflammatory cytokines. ABB071 can be used for research on systemic lupus erythematosus and psoriasis[1].

IC50 & Target[1].

TLR7

 

In Vitro

ABB071 inhibits lSGs induced by ligands for TLR7 TLR8, TLR9, CGAS-STING, as well as lFNa in B cells from normal donors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ABB071 Related Antibodies
In Vivo

ABB071 reduces the psoriasis area and severity index score, decreases the levels of key inflammatory cytokines and does not result in circulating proinflammatory cytokines such as lL-6, TNF-a, and IFN-γ in the skin in Imiquimod (HY-B0180)-induced psoriasis mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SMILES

[ABB071]
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Purity & Documentation
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ABB071 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABB071ABB 071ABB-071Transmembrane GlycoproteinToll-like Receptor (TLR)Inhibitorinhibitorinhibit

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