Fbxl2 - F-box and leucine-rich repeat protein 2 Gene

Also Known as Fbl3; 2810423A21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72179

Summary

Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity and protein Phosphatase binding activity. Acts upstream of or within protein monoubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of SCF ubiquitin Ligase complex. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human FBXL2 (F-box and leucine rich repeat protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Fbxl2 Products (1)

mRNA Protein Name
NM_178624.6 NP_848739.1 F-box/LRR-repeat protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21343341 MGI
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
23542741 MGI
Biological Process GO Annotation Evidence References Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
23542741 MGI
acts upstream of or within protein monoubiquitination IGI
IGI: Inferred from genetic interaction
21343341 MGI
acts upstream of or within protein monoubiquitination IMP
IMP: Inferred from mutant phenotype
21343341 MGI
involved in regulation of inflammatory response IDA
IDA: Inferred from direct assay
23542741 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
21343341 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box/LRR-repeat protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-129087 BC-​1258 Inducer 99.85% Unkown
HY-RS04789 FBXL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18815 Fbxl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25305 Fbxl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbxl2 NCBI NCBI:25827