2. Apoptosis
  3. Apoptosis
  4. BC-​1258

BC-​1258 

Cat. No.: HY-129087
Handling Instructions

BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice.

For research use only. We do not sell to patients.

BC-​1258 Chemical Structure

BC-​1258 Chemical Structure

CAS No. : 1507370-40-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].

IC50 & Target

FBXL2[1]
In Vitro

BC-1258 是一种 F-box/LRR-重复蛋白 2 (FBXL2) 激活剂，可以稳定和上调 FBXL2 水平。BC-1258 诱导致瘤细胞凋亡，并显着抑制小鼠的肿瘤形成。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MLE cells
Concentration: 2, 10, 50 μg/mL
Incubation Time: 16 hours
Result: Significantly increased the cell population within the G2/M phase.
Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: U937, K562 and THP1 cells
Concentration: 2, 10 μg/mL
Incubation Time: 16 hours
Result: Increased FBXL2 protein levels.
Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.
In Vivo

BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

406.57

Formula

C22H22N4S2
CAS No.
SMILES

C1(CNCCNCC2=CC=C(C3=NC=CS3)C=C2)=CC=C(C4=NC=CS4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BC-​12581507370-40-2ApoptosisF-boxLRRrepeatFBXL2apoptosistumorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BC-​1258
Cat. No.:
HY-129087
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email address *

Phone number

 

Department *

Organization name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.