2. Apoptosis
  3. Apoptosis
  4. BC-​1258

BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice.

For research use only. We do not sell to patients.

BC-​1258 Chemical Structure

BC-​1258 Chemical Structure

CAS No. : 1507370-40-2

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Based on 1 publication(s) in Google Scholar

BC-​1258 Related Antibodies

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  • Biological Activity

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Description

BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].

IC50 & Target

FBXL2[1]
In Vitro

BC-1258 是一种 F-box/LRR-重复蛋白 2 (FBXL2) 激活剂，可以稳定和上调 FBXL2 水平。BC-1258 诱导致瘤细胞凋亡，并显着抑制小鼠的肿瘤形成。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BC-​1258 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: MLE cells
Concentration: 2, 10, 50 μg/mL
Incubation Time: 16 hours
Result: Significantly increased the cell population within the G2/M phase.
Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: U937, K562 and THP1 cells
Concentration: 2, 10 μg/mL
Incubation Time: 16 hours
Result: Increased FBXL2 protein levels.
Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.
In Vivo

BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

406.57

Formula

C22H22N4S2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

C1(CNCCNCC2=CC=C(C3=NC=CS3)C=C2)=CC=C(C4=NC=CS4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (307.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4596 mL 12.2980 mL 24.5960 mL
5 mM 0.4919 mL 2.4596 mL 4.9192 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4596 mL 12.2980 mL 24.5960 mL 61.4900 mL
5 mM 0.4919 mL 2.4596 mL 4.9192 mL 12.2980 mL
10 mM 0.2460 mL 1.2298 mL 2.4596 mL 6.1490 mL
15 mM 0.1640 mL 0.8199 mL 1.6397 mL 4.0993 mL
20 mM 0.1230 mL 0.6149 mL 1.2298 mL 3.0745 mL
25 mM 0.0984 mL 0.4919 mL 0.9838 mL 2.4596 mL
30 mM 0.0820 mL 0.4099 mL 0.8199 mL 2.0497 mL
40 mM 0.0615 mL 0.3075 mL 0.6149 mL 1.5373 mL
50 mM 0.0492 mL 0.2460 mL 0.4919 mL 1.2298 mL
60 mM 0.0410 mL 0.2050 mL 0.4099 mL 1.0248 mL
80 mM 0.0307 mL 0.1537 mL 0.3075 mL 0.7686 mL
100 mM 0.0246 mL 0.1230 mL 0.2460 mL 0.6149 mL
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BC-​1258 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BC-​12581507370-40-2ApoptosisF-boxLRRrepeatFBXL2apoptosistumorInhibitorinhibitorinhibit

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