1. Apoptosis
  2. Apoptosis
  3. BC-​1258

BC-​1258 

Cat. No.: HY-129087
Handling Instructions

BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice.

For research use only. We do not sell to patients.

BC-​1258 Chemical Structure

BC-​1258 Chemical Structure

CAS No. : 1507370-40-2

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Description

BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].

IC50 & Target

FBXL2[1]

In Vitro

BC-1258 是一种 F-box/LRR-重复蛋白 2 (FBXL2) 激活剂,可以稳定和上调 FBXL2 水平。BC-1258 诱导致瘤细胞凋亡,并显着抑制小鼠的肿瘤形成。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MLE cells
Concentration: 2, 10, 50 μg/mL
Incubation Time: 16 hours
Result: Significantly increased the cell population within the G2/M phase.
Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: U937, K562 and THP1 cells
Concentration: 2, 10 μg/mL
Incubation Time: 16 hours
Result: Increased FBXL2 protein levels.
Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.
In Vivo

BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

406.57

Formula

C₂₂H₂₂N₄S₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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BC-​1258
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HY-129087
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