BC-1258
Based on 1 publication(s) in Google Scholar
BC-1258，an F-box/LRR-repeat protein 2 (FBXL2) activator，can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells，and profoundly inhibits tumor formation in mice.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 1507370-40-2
- Formula: C22H22N4S2
- Molecular Weight:406.57
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Anti-Cancer Compound Library
HY-L025
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Heterocyclic Compound Library
HY-L138
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
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Publications Citing Use of MedChemExpress (MCE) BC-1258
More
Biological Activity
FBXL2[1]
BC-1258 is an F-box/LRR-repeat protein 2 (FBXL2) activator that can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells and significantly inhibits tumor formation in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MLE cells
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Concentration:2, 10, 50 μg/mL
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Incubation Time:16 hours
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Result:Significantly increased the cell population within the G2/M phase.
Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner.
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Cell Line:U937, K562 and THP1 cells
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Concentration:2, 10 μg/mL
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Incubation Time:16 hours
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Result:Increased FBXL2 protein levels.
Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1507370-40-2
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Appearance Solid
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Molecular Weight 406.57
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Formula C22H22N4S2
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Color Off-white to light yellow
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SMILES
C1(CNCCNCC2=CC=C(C3=NC=CS3)C=C2)=CC=C(C4=NC=CS4)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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BMC Pulm Med
2024 Oct 29;24(1):542. PMID: 39472837
Solvent & Solubility
DMSO : 125 mg/mL (307.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4596 mL | 12.2980 mL | 24.5960 mL | 61.4900 mL |
| 5 mM | 0.4919 mL | 2.4596 mL | 4.9192 mL | 12.2980 mL | |
| 10 mM | 0.2460 mL | 1.2298 mL | 2.4596 mL | 6.1490 mL | |
| 15 mM | 0.1640 mL | 0.8199 mL | 1.6397 mL | 4.0993 mL | |
| 20 mM | 0.1230 mL | 0.6149 mL | 1.2298 mL | 3.0745 mL | |
| 25 mM | 0.0984 mL | 0.4919 mL | 0.9838 mL | 2.4596 mL | |
| 30 mM | 0.0820 mL | 0.4099 mL | 0.8199 mL | 2.0497 mL | |
| 40 mM | 0.0615 mL | 0.3075 mL | 0.6149 mL | 1.5373 mL | |
| 50 mM | 0.0492 mL | 0.2460 mL | 0.4919 mL | 1.2298 mL | |
| 60 mM | 0.0410 mL | 0.2050 mL | 0.4099 mL | 1.0248 mL | |
| 80 mM | 0.0307 mL | 0.1537 mL | 0.3075 mL | 0.7686 mL | |
| 100 mM | 0.0246 mL | 0.1230 mL | 0.2460 mL | 0.6149 mL |
BC-1258 Related Classifications
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