TST - thiosulfate sulfurtransferase Gene

Also Known as RDS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7263

About TST

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:37,010,859-37,020,183 (from NCBI)

This gene has 4 transcripts (splice variants), 295 orthologues and 1 paralogue. Broad expression in colon (RPKM 83.2), liver (RPKM 73.2) and 22 other tissues.

Summary

This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

TST Products (2)

mRNA Protein Name
NM_001270483.1 NP_001257412.1 thiosulfate sulfurtransferase
NM_003312.6 NP_003303.2 thiosulfate sulfurtransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 5S rRNA binding IDA
IDA: Inferred from direct assay
20663881 GOA
Biological Process GO Annotation Evidence References Source
involved in epithelial cell differentiation IDA
IDA: Inferred from direct assay
21492153 GOA
involved in rRNA import into mitochondrion IMP
IMP: Inferred from mutant phenotype
20663881 GOA
involved in rRNA transport IDA
IDA: Inferred from direct assay
21685364 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TST Protein Structure

Rhodanese

Rhodanese: Rhodanese-like domain (14 - 136)

Rhodanese

Rhodanese: Rhodanese-like domain (165 - 280)

  • 0
  • 100
  • 200
  • 297 a.a.
Protein Preferred Names Protein Names

thiosulfate sulfurtransferase

  • epididymis secretory sperm binding protein

Related Diseases

Diseases Alias
Commensal Bacterial Infectious Disease
Staphyloenterotoxemia

  • Staphylococcal Food Poisoning

  • Staphylococcal Toxaemia Due To Food

  • Staphyloenterotoxicosis
Ritter'S Disease

  • Staphylococcal Scalded Skin Syndrome

  • Pemphigus Neonatorum

  • Ritter Disease

  • Dermatitis Exfoliativa Neonatorum

  • Scalded Skin Syndrome

  • Toxic Epidermal Necrolysis, Subcorneal Type

  • Generalized Exfoliative Disease

  • Ssss

  • Ssss - [Staphylococcal Scalded Skin Syndrome]
Encephalopathy, Ethylmalonic

  • Ethylmalonic Encephalopathy

  • EE

  • Epema Syndrome

  • Encephalopathy, Petechiae, And Ethylmalonic Aciduria

  • Ethe1 Deficiency

  • Eme

  • Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Pyomyositis

  • Tropical Pyomyositis

  • Myositis Tropicans

  • Myositis Purulenta Tropica

  • Pm

  • Suppurative Myositis

  • Purulent Myositis
Endocardium Disease
Scarlet Fever

  • Scarlatina

  • Scarlatina Nos
Carbuncle

  • Carbuncle And Furuncle Of Any Part Of Face Except Eye

  • Carbuncle And Furuncle Of Buttock

  • Carbuncle And Furuncle Of Face

  • Carbuncle And Furuncle Of Foot

  • Carbuncle And Furuncle Of Gluteal Region

  • Carbuncle And Furuncle Of Hand

  • Carbuncle And Furuncle Of Leg Except Foot

  • Carbuncle And Furuncle Of Neck

  • Carbuncle And Furuncle Of Trunk

  • Carbuncle And Furuncle Of Upper Arm And Forearm
Infective Endocarditis

  • Bacterial Endocarditis

  • Endocarditis, Infective

  • Infectious Endocarditis

  • Endocarditis Infective
Discitis
Necrotizing Fasciitis

  • Fasciitis, Necrotizing
Impetigo
Septic Arthritis

  • Infectious Arthritis

  • Arthritis, Infectious

  • Arthritis Septic

  • Arthritis, Bacterial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1395 Mecamylamine hydrochloride 98.0% Yes
HY-B1395A Mecamylamine ≥90.0% Unkown

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P9991 Osemitamab Inhibitor 99.43% Phase 2

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W105505 SAMe-1,4-Butanedisulfonate 98.03% Unkown
HY-147735 GABAA receptor agonist 1 Agonist / Unkown
HY-147736 GABAA receptor agonist 2 Agonist / Unkown
HY-162775 TST1N-224 Inhibitor / Unkown
HY-RS15190 TST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15191 TSTD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17363 Tst Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23817 Tst Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W143822 6-(Tritylthio)hexanoic acid / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TST VGNC VGNC:36449
Mus musculus TST MGD MGI:98852
Felis catus TST VGNC VGNC:66647
Canis familiaris TST VGNC VGNC:47932
Rattus norvegicus TST RGD RGD:3913
Macaca mulatta TST VGNC VGNC:78664
Others TST NCBI