TST - thiosulfate sulfurtransferase Gene

Homo sapiens

Also known as RDS

Gene ID: 7263 | Gene type: protein coding

About TST

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:37,010,859-37,020,183 (from NCBI)

This gene has 4 transcripts (splice variants), 295 orthologues and 1 paralogue. Broad expression in colon (RPKM 83.2), liver (RPKM 73.2) and 22 other tissues.

Summary

This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

TST Products(2)

mRNA	Protein	Name
NM_001270483.1	NP_001257412.1	thiosulfate sulfurtransferase
NM_003312.6	NP_003303.2	thiosulfate sulfurtransferase

TST Protein Structure

Rhodanese

0
100
200
297 a.a.

Protein Preferred Names

Protein Names

thiosulfate sulfurtransferase

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Commensal Bacterial Infectious Disease

Staphyloenterotoxemia

Staphylococcal Food Poisoning	Staphylococcal Toxaemia Due To Food
Staphyloenterotoxicosis

Ritter'S Disease

Staphylococcal Scalded Skin Syndrome	Pemphigus Neonatorum
Ritter Disease	Dermatitis Exfoliativa Neonatorum
Scalded Skin Syndrome	Toxic Epidermal Necrolysis, Subcorneal Type
Generalized Exfoliative Disease	Ssss
Ssss - [Staphylococcal Scalded Skin Syndrome]

Encephalopathy, Ethylmalonic

Ethylmalonic Encephalopathy	EE
Epema Syndrome	Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Ethe1 Deficiency	Eme
Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria

Pyomyositis

Tropical Pyomyositis	Myositis Tropicans
Myositis Purulenta Tropica	Pm
Suppurative Myositis	Purulent Myositis

Endocardium Disease

Scarlet Fever

Scarlatina

Scarlatina Nos

Carbuncle

Carbuncle And Furuncle Of Any Part Of Face Except Eye	Carbuncle And Furuncle Of Buttock
Carbuncle And Furuncle Of Face	Carbuncle And Furuncle Of Foot
Carbuncle And Furuncle Of Gluteal Region	Carbuncle And Furuncle Of Hand
Carbuncle And Furuncle Of Leg Except Foot	Carbuncle And Furuncle Of Neck
Carbuncle And Furuncle Of Trunk	Carbuncle And Furuncle Of Upper Arm And Forearm

Infective Endocarditis

Bacterial Endocarditis	Endocarditis, Infective
Infectious Endocarditis	Endocarditis Infective

Discitis

Necrotizing Fasciitis

Fasciitis, Necrotizing

Impetigo

Septic Arthritis

Infectious Arthritis	Arthritis, Infectious
Arthritis Septic	Arthritis, Bacterial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1395A	Mecamylamine		/	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147735	GABAA receptor agonist 1	Agonist	/	Unkown
HY-147736	GABAA receptor agonist 2	Agonist	/	Unkown
HY-RS15190	TST Human Pre-designed siRNA Set A		/	Unkown
HY-W105505	SAMe-1,4-Butanedisulfonate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TST	VGNC	VGNC:36449
Mus musculus	TST	MGD	MGI:98852
Felis catus	TST	VGNC	VGNC:66647
Canis familiaris	TST	VGNC	VGNC:47932
Rattus norvegicus	TST	RGD	RGD:3913
Macaca mulatta	TST	VGNC	VGNC:78664
Others	TST	NCBI

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