Scn2b - sodium channel, voltage-gated, type II, beta Gene

Also Known as Gm183; 2810451E09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72821

Summary

Predicted to enable Sodium Channel regulator activity and voltage-gated Sodium Channel activity involved in cardiac muscle cell action potential. Predicted to be involved in several processes, including cardiac muscle cell action potential; regulation of atrial cardiac muscle cell membrane depolarization; and regulation of heart rate by cardiac conduction. Predicted to act upstream of or within regulation of ion transmembrane transport and sodium ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated Sodium Channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cranial ganglion and dorsal root ganglion. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human SCN2B (sodium voltage-gated channel beta subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Scn2b Products (1)

mRNA Protein Name
NM_001014761.2 NP_001014761.1 sodium channel subunit beta-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IMP
IMP: Inferred from mutant phenotype
27932425 MGI
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
27932425 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive effect cardiac conduction IMP
IMP: Inferred from mutant phenotype
27932425 MGI
acts upstream of or within positive effect gene expression IMP
IMP: Inferred from mutant phenotype
16870743 MGI
acts upstream of or within response to heat IMP
IMP: Inferred from mutant phenotype
16870743 MGI
acts upstream of or within sodium ion transport IMP
IMP: Inferred from mutant phenotype
16870743 MGI
Cellular Component GO Annotation Evidence References Source
is active in T-tubule IDA
IDA: Inferred from direct assay
27932425 MGI
located in T-tubule IDA
IDA: Inferred from direct assay
27932425 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium channel subunit beta-2

  • sodium channel, voltage-gated, type II, beta polypeptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12532 SCN2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20102 Scn2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26605 Scn2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn2b NCBI NCBI:6327