Pear1 - platelet endothelial aggregation receptor 1 Gene

Also Known as Jedi-1; Megf12; 3110045G13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 73182

Summary

Enables signaling receptor activity. Involved in phosphatidylinositol 3-kinase signaling; platelet aggregation; and protein kinase B signaling. Acts upstream of or within recognition of apoptotic cell. Located in phagocytic cup. Is active in plasma membrane. Is expressed in brain; dorsal root ganglion; embryo; and heart. Orthologous to human PEAR1 (platelet endothelial aggregation receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Pear1 Products (6)

mRNA Protein Name
NM_001032413.1 NP_001027585.1 platelet endothelial aggregation receptor 1 isoform a precursor
NM_001032414.1 NP_001027586.1 platelet endothelial aggregation receptor 1 isoform a precursor
NM_001289600.1 NP_001276529.1 platelet endothelial aggregation receptor 1 isoform b
NM_001289601.1 NP_001276530.1 platelet endothelial aggregation receptor 1 isoform c
NM_028460.2 NP_082736.1 platelet endothelial aggregation receptor 1 isoform a precursor
NM_152799.2 NP_690012.2 platelet endothelial aggregation receptor 1 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables signaling receptor activity IDA
IDA: Inferred from direct assay
27614188 MGI
Biological Process GO Annotation Evidence References Source
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
27614188 MGI
involved in platelet aggregation IDA
IDA: Inferred from direct assay
27614188 MGI
involved in positive regulation of platelet activation IMP
IMP: Inferred from mutant phenotype
36792666 MGI
acts upstream of or within recognition of apoptotic cell IDA
IDA: Inferred from direct assay
19915564 MGI
acts upstream of or within recognition of apoptotic cell IMP
IMP: Inferred from mutant phenotype
19915564 MGI
Cellular Component GO Annotation Evidence References Source
located in phagocytic cup IDA
IDA: Inferred from direct assay
19915564 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
27614188 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet endothelial aggregation receptor 1

  • Jedi

  • jagged and Delta protein

  • mPEAR1

  • multiple EGF-like domains protein 12

  • multiple epidermal growth factor-like domains protein 12

  • protein Jedi

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10312 PEAR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18541 Pear1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25023 Pear1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pear1 NCBI NCBI:375033