Atat1 - alpha tubulin acetyltransferase 1 Gene

Also Known as TAT; Mec17; MEC-17; 0610011P08Rik; 2610008K08Rik; 2610110G12Rik; 3110080J08Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 73242

Summary

Enables tubulin N-acetyltransferase activity. Acts upstream of or within several processes, including alpha-tubulin acetylation; dentate gyrus development; and positive regulation of NLRP3 inflammasome complex assembly. Located in microtubule bundle. Is expressed in several structures, including adrenal gland; central nervous system; gut; male reproductive gland or organ; and neural retina. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Atat1 Products (5)

mRNA	Protein	Name
NM_001142744.1	NP_001136216.1	alpha-tubulin N-acetyltransferase 1 isoform 1
NM_001142745.1	NP_001136217.1	alpha-tubulin N-acetyltransferase 1 isoform 2
NM_001347378.1	NP_001334307.1	alpha-tubulin N-acetyltransferase 1 isoform 4
NM_001357865.1	NP_001344794.1	alpha-tubulin N-acetyltransferase 1 isoform 5
NM_028476.4	NP_082752.3	alpha-tubulin N-acetyltransferase 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables acetyltransferase activity	IMP IMP: Inferred from mutant phenotype	27976998	MGI
enables tubulin N-acetyltransferase activity	IDA IDA: Inferred from direct assay	20829795	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	23502856	MGI
acts upstream of or within alpha-tubulin acetylation	IMP IMP: Inferred from mutant phenotype	23126280	MGI
acts upstream of or within dentate gyrus development	IMP IMP: Inferred from mutant phenotype	23720746	MGI
involved in microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	27976998	MGI
acts upstream of or within positive regulation of NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	23502856	MGI
acts upstream of or within regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23126280	MGI
involved in response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	27976998	MGI
involved in response to pain	IMP IMP: Inferred from mutant phenotype	27976998	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	23748901	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in membrane	IDA IDA: Inferred from direct assay	27976998	MGI
located in microtubule bundle	IDA IDA: Inferred from direct assay	23720746	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
alpha-tubulin N-acetyltransferase 1	acetyltransferase mec-17 homolog alpha-TAT alpha-TAT1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01124	ATAT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19656	Atat1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26149	Atat1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atat1	NCBI	NCBI:79969