UBE2L3 - ubiquitin conjugating enzyme E2 L3 Gene

Also Known as E2-F1; L-UBC; UBCH7; UbcM4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7332

About UBE2L3

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:21,549,447-21,624,034 (from NCBI)

This gene has 5 transcripts (splice variants), 159 orthologues, 12 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 19.5), urinary bladder (RPKM 19.0) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes (E1s), ubiquitin-conjugating Enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

UBE2L3 Products (3)

mRNA	Protein	Name
NM_001256355.1	NP_001243284.1	ubiquitin-conjugating enzyme E2 L3 isoform 4
NM_001256356.2	NP_001243285.1	ubiquitin-conjugating enzyme E2 L3 isoform 3
NM_003347.4	NP_003338.1	ubiquitin-conjugating enzyme E2 L3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9990509	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	15367689	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: Inferred from direct assay	20061386	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11278816	GOA
enables ubiquitin-protein transferase activator activity	IGI IGI: Inferred from genetic interaction	12628165	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	14765125	GOA
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	10888878	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell cycle phase transition	IMP IMP: Inferred from mutant phenotype	18946090	GOA
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	18946090	GOA
involved in cellular response to glucocorticoid stimulus	IDA IDA: Inferred from direct assay	17003263	GOA
involved in cellular response to steroid hormone stimulus	IMP IMP: Inferred from mutant phenotype	15367689	GOA
involved in positive regulation of protein ubiquitination	IGI IGI: Inferred from genetic interaction	12628165	GOA
involved in positive regulation of ubiquitin-protein transferase activity	IGI IGI: Inferred from genetic interaction	12628165	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	10888878	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	9990509	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17003263	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15367689	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9990509	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11278816	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2L3 Protein Structure

UQ_con

0
100
154 a.a.

Protein Preferred Names	Protein Names
ubiquitin-conjugating enzyme E2 L3	E2 ubiquitin-conjugating enzyme L3

UBE2L3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBE2L3	P68036	RNF182	Homo sapiens	Q8N6D2	Y2H Prey Pooling	32296183
Intra	UBE2L3	P68036	RNF182	Homo sapiens	Q8N6D2	Validated Y2H	32296183
Intra	UBE2L3	P68036	RNF182	Homo sapiens	Q8N6D2	Y2H Array	32296183
Intra	UBE2L3	P68036	MID1	Homo sapiens	O15344	Y2H Prey Pooling	32296183
Intra	UBE2L3	P68036	MID1	Homo sapiens	O15344	Y2H Array	32296183
Intra	UBE2L3	P68036	RBCK1	Homo sapiens	Q9BYM8	Y2H Array	19549727
Intra	UBE2L3	P68036	RBCK1	Homo sapiens	Q9BYM8	Y2H Prey Pooling	32296183
Intra	UBE2L3	P68036	RBCK1	Homo sapiens	Q9BYM8	Validated Y2H	32296183
Intra	UBE2L3	P68036	RBCK1	Homo sapiens	Q9BYM8	Y2H Array	32296183
Intra	UBE2L3	P68036	RNF144A	Homo sapiens	P50876	Y2H Prey Pooling	32296183
Intra	UBE2L3	P68036	RNF144A	Homo sapiens	P50876	Y2H Array	32296183
Intra	UBE2L3	P68036	RNF19B	Homo sapiens	Q6ZMZ0	Anti Bait CoIP	16709802
Intra	UBE2L3	P68036	ARIH2	Homo sapiens	O95376	Anti Tag CoIP	33961781
Intra	UBE2L3	P68036	RNF216	Homo sapiens	Q9NWF9	Y2H Prey Pooling	32296183
Intra	UBE2L3	P68036	RNF216	Homo sapiens	Q9NWF9	Validated Y2H	32296183
Intra	UBE2L3	P68036	RNF216	Homo sapiens	Q9NWF9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2L3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79451	UbcH7/UBE2L3 Protein, Human	P68036-1 (M1-D154)	≥ 95%, as determined by reducing SDS-PAGE.

UBE2L3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83558	Ubiquitin Conjugating Enzyme E2 L3 Antibody (YA3303)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P83558A	Ubiquitin Conjugating Enzyme E2 L3 Antibody (YA3303)(PBS only)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Papilloma	Papillomatosis
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Glycogen Storage Disease Iv	Gsd Iv Glycogen Branching Enzyme Deficiency Andersen Disease Amylopectinosis Glycogen Storage Disease Type Iv GSD4 Brancher Deficiency Glycogen Storage Disease, Type Iv Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Gbe1 Deficiency Glycogenosis Iv Cirrhosis, Familial, With Deposition Of Abnormal Glycogen Glycogen Storage Disease Type 4 Glycogenosis 4 Potassium-Sensitive Periodic Paralysis, Ventricular Ectopy, And Dysmorphic Features Andersen'S Disease Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Brancher Deficiency Glycogenosis Branching-Transferase Deficiency Glycogenosis Deficiency Of 1,4-Alpha-Glucan Branching Enzyme Andersen-Tawil Syndrome Gsd 4 Andersen Cardiodysrhythmic Periodic Paralysis Lqt7 Long Qt Syndrome 7 Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type Andersen Glycogenosis Branching Enzyme Deficiency Glycogenosis, Type Iv Gsd Type Iv Type Iv Glycogenosis Gbe Deficiency, Childhood Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Gsd Type 4, Childhood Neuromuscular Form Gsdiv, Childhood Neuromuscular Form Glycogen Storage Disease Type 4, Childhood Neuromuscular Form Glycogen Storage Disease Type Iv, Childhood Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Glycogenosis Type 4, Childhood Neuromuscular Form Glycogenosis Type Iv, Childhood Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Gbe Deficiency, Adult Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Gsd Type 4, Adult Neuromuscular Form Gsdiv, Adult Neuromuscular Form Glycogen Storage Disease Type 4, Adult Neuromuscular Form Glycogen Storage Disease Type Iv, Adult Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Glycogenosis Type 4, Adult Neuromuscular Form Glycogenosis Type Iv, Adult Neuromuscular Form Gbe Deficiency, Congenital Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Gsd Type 4, Congenital Neuromuscular Form Gsdiv, Congenital Neuromuscular Form Glycogen Storage Disease Type 4, Congenital Neuromuscular Form Glycogen Storage Disease Type Iv, Congenital Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Glycogenosis Type 4, Congenital Neuromuscular Form Glycogenosis Type Iv, Congenital Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Gbe Deficiency, Childhood Combined Hepatic And Myopathic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Gsd Type 4, Childhood Combined Hepatic And Myopathic Form Gsdiv, Childhood Combined Hepatic And Myopathic Form Glycogen Storage Disease Type 4, Childhood Combined Hepatic And Myopathic Form Glycogen Storage Disease Type Iv, Childhood Combined Hepatic And Myopathic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Glycogenosis Type 4, Childhood Combined Hepatic And Myopathic Form Glycogenosis Type Iv, Childhood Combined Hepatic And Myopathic Form Gbe Deficiency, Fatal Perinatal Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Gsd Type 4, Fatal Perinatal Neuromuscular Form Gsdiv, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Type 4, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Type Iv, Fatal Perinatal Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Glycogenosis Type 4, Fatal Perinatal Neuromuscular Form Glycogenosis Type Iv, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Gbe Deficiency, Non Progressive Hepatic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Gsd Type 4, Non Progressive Hepatic Form Gsdiv, Non Progressive Hepatic Form Glycogen Storage Disease Type 4, Non Progressive Hepatic Form Glycogen Storage Disease Type Iv, Non Progressive Hepatic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Glycogenosis Type 4, Non Progressive Hepatic Form Glycogenosis Type Iv, Non Progressive Hepatic Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Gbe Deficiency, Progressive Hepatic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Gsd Type 4, Progressive Hepatic Form Gsdiv, Progressive Hepatic Form Glycogen Storage Disease Type 4, Progressive Hepatic Form Glycogen Storage Disease Type Iv, Progressive Hepatic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Glycogenosis Type 4, Progressive Hepatic Form Glycogenosis Type Iv, Progressive Hepatic Form Glycogen Storage Disease 4 Gsd-Iv Storage Disease, Glycogen, Type Iv
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0753	Eupalinolide B		99.48%	Unkown
HY-RS15341	UBE2D3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15344	UBE2E3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15353	UBE2L3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19825	Ube2d3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26321	Ube2d3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBE2L3	RGD	RGD:1308361
Bos taurus	UBE2L3	VGNC	VGNC:53927
Mus musculus	UBE2L3	MGD	MGI:109240
Others	UBE2L3	NCBI