RNF144A - ring finger protein 144A Gene

Also Known as UIP4; hUIP4; RNF144; UBCE7IP4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9781

About RNF144A

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:6,917,412-7,076,367 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 9 paralogues. Ubiquitous expression in adrenal (RPKM 4.0), endometrium (RPKM 3.6) and 24 other tissues.

Summary

This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]

RNF144A Products (7)

mRNA Protein Name
NM_001349181.2 NP_001336110.1 E3 ubiquitin-protein ligase RNF144A isoform 1
NM_001349182.2 NP_001336111.1 E3 ubiquitin-protein ligase RNF144A isoform 2
NM_001349183.2 NP_001336112.1 E3 ubiquitin-protein ligase RNF144A isoform 2
NM_001349184.2 NP_001336113.1 E3 ubiquitin-protein ligase RNF144A isoform 2
NM_001349185.2 NP_001336114.1 E3 ubiquitin-protein ligase RNF144A isoform 3
NM_001349186.2 NP_001336115.1 E3 ubiquitin-protein ligase RNF144A isoform 4
NM_014746.6 NP_055561.2 E3 ubiquitin-protein ligase RNF144A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19549727 GOA
enables ubiquitin protein ligase activity EXP
EXP: Inferred from Experiment
24979766 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
37955227 GOA
Biological Process GO Annotation Evidence References Source
involved in pattern recognition receptor signaling pathway IDA
IDA: Inferred from direct assay
37955227 GOA
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
37955227 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10942595 GOA
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
37955227 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF144A Protein Structure

IBR

IBR: IBR domain, a half RING-finger domain (91 - 156)

IBR

IBR: IBR domain, a half RING-finger domain (177 - 217)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF144A

  • UbcM4-interacting protein 4

RNF144A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF144A P50876 DGAT2L6 Homo sapiens Q6ZPD8
Validated Y2H
32296183
Intra
RNF144A P50876 PAQR6 Homo sapiens Q6TCH4
Validated Y2H
32296183
Intra
RNF144A P50876 MFSD5 Homo sapiens Q6N075
Validated Y2H
32296183
Intra
RNF144A P50876 RFT1 Homo sapiens Q96AA3
Validated Y2H
32296183
Intra
RNF144A P50876 RFT1 Homo sapiens Q96AA3
Y2H Array
32296183
Intra
RNF144A P50876 CKAP4 Homo sapiens Q07065
Anti Tag CoIP
33961781
Intra
RNF144A P50876 CKAP4 Homo sapiens Q07065
Anti Tag CoIP
28514442
Intra
RNF144A P50876 UBE2L3 Homo sapiens P68036
Y2H Array
19549727
Intra
RNF144A P50876 UBE2L3 Homo sapiens P68036
Validated Y2H
32296183
Intra
RNF144A P50876 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
RNF144A P50876 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RNF144A Antibodies

Cat. No. Product Name Application Reactivity
HY-P810963 RNF144A Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12053 RNF144A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RNF144A VGNC VGNC:45635
Felis catus RNF144A VGNC VGNC:64673
Rattus norvegicus RNF144A RGD RGD:1561737
Bos taurus RNF144A VGNC VGNC:34026
Macaca mulatta RNF144A VGNC VGNC:106212
Mus musculus RNF144A MGD MGI:1344401
Others RNF144A NCBI