Sgms2 - sphingomyelin synthase 2 Gene

Also Known as 4933405A16Rik; 5133401H06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74442

Summary

Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. [provided by RefSeq, Oct 2008]

Sgms2 Products (7)

mRNA Protein Name
NM_001379582.1 NP_001366511.1 phosphatidylcholine:ceramide cholinephosphotransferase 2
NM_001379583.1 NP_001366512.1 phosphatidylcholine:ceramide cholinephosphotransferase 2
NM_001379584.1 NP_001366513.1 phosphatidylcholine:ceramide cholinephosphotransferase 2
NM_001379585.1 NP_001366514.1 phosphatidylcholine:ceramide cholinephosphotransferase 2
NM_001379586.1 NP_001366515.1 phosphatidylcholine:ceramide cholinephosphotransferase 2
NM_001379587.1 NP_001366516.1 phosphatidylcholine:ceramide cholinephosphotransferase 2
NM_028943.6 NP_083219.2 phosphatidylcholine:ceramide cholinephosphotransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ceramide phosphoethanolamine synthase activity IMP
IMP: Inferred from mutant phenotype
25605874 MGI
enables sphingomyelin synthase activity IDA
IDA: Inferred from direct assay
27892528 MGI
enables sphingomyelin synthase activity IMP
IMP: Inferred from mutant phenotype
25667419 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
25605874 MGI
acts upstream of or within ceramide phosphoethanolamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
25667419 MGI
acts upstream of or within sphingomyelin biosynthetic process IMP
IMP: Inferred from mutant phenotype
25667419 MGI
involved in sphingomyelin biosynthetic process IMP
IMP: Inferred from mutant phenotype
27892528 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylcholine:ceramide cholinephosphotransferase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12806 SGMS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19237 Sgms2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25726 Sgms2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sgms2 NCBI NCBI:166929