Pank2 - pantothenate kinase 2 Gene

Also Known as hPanK2; 4933409I19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74450

Summary

Enables pantothenate kinase activity. Acts upstream of or within several processes, including coenzyme A biosynthetic process; mitochondrion morphogenesis; and spermatid development. Located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in pantothenate kinase-associated neurodegeneration. Orthologous to human PANK2 (pantothenate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Pank2 Products (10)

mRNA Protein Name
NM_001355679.1 NP_001342608.1 pantothenate kinase 2, mitochondrial isoform b
NM_001355681.1 NP_001342610.1 pantothenate kinase 2, mitochondrial isoform c
NM_001355682.1 NP_001342611.1 pantothenate kinase 2, mitochondrial isoform c
NM_001355683.1 NP_001342612.1 pantothenate kinase 2, mitochondrial isoform d
NM_153501.3 NP_705721.3 pantothenate kinase 2, mitochondrial isoform a
NM_001355679.1 NP_001342608.1 pantothenate kinase 2, mitochondrial isoform b
NM_001355681.1 NP_001342610.1 pantothenate kinase 2, mitochondrial isoform c
NM_001355682.1 NP_001342611.1 pantothenate kinase 2, mitochondrial isoform c
NM_001355683.1 NP_001342612.1 pantothenate kinase 2, mitochondrial isoform d
NM_153501.3 NP_705721.3 pantothenate kinase 2, mitochondrial isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables pantothenate kinase activity IDA
IDA: Inferred from direct assay
17825826 MGI
enables pantothenate kinase activity IGI
IGI: Inferred from genetic interaction
11479594 MGI
enables pantothenate kinase activity IMP
IMP: Inferred from mutant phenotype
17379144 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within aerobic respiration IMP
IMP: Inferred from mutant phenotype
22983956 MGI
involved in coenzyme A biosynthetic process IGI
IGI: Inferred from genetic interaction
22815849 MGI
acts upstream of or within coenzyme A biosynthetic process IMP
IMP: Inferred from mutant phenotype
22815849 MGI
involved in coenzyme A biosynthetic process IMP
IMP: Inferred from mutant phenotype
24316510 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
22983956 MGI
acts upstream of or within regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
22983956 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
15525657 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
17825826 MGI
is active in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
22983956 MGI
NOT located in mitochondrion IDA
IDA: Inferred from direct assay
17825826 MGI
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
22983956 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pantothenate kinase 2, mitochondrial

  • pantothenate kinase 2 (Hallervorden-Spatz syndrome)

  • pantothenic acid kinase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-44170 Pantothenate kinase-IN-2 Inhibitor 98.18% Unkown
HY-159509 Claziprotamidum Modulator 98.33% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pank2 NCBI NCBI:80025