Abhd12 - abhydrolase domain containing 12 Gene

Also Known as 1500011G07Rik; 6330583M11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76192

Summary

Enables acylglycerol Lipase activity; lysophospholipase activity; and palmitoyl-(protein) hydrolase activity. Involved in cellular lipid catabolic process; protein depalmitoylation; and regulation of inflammatory response. Acts upstream of or within adult walking behavior; phosphatidylserine catabolic process; and response to auditory stimulus. Located in dendrite cytoplasm and endoplasmic reticulum membrane. Is integral component of membrane. Part of AMPA glutamate receptor complex. Used to study PHARC syndrome. Human ortholog(s) of this gene implicated in PHARC syndrome. Orthologous to human ABHD12 (abhydrolase domain containing 12, lysophospholipase). [provided by Alliance of Genome Resources, Apr 2022]

Abhd12 Products (3)

mRNA Protein Name
NM_001356549.1 NP_001343478.1 lysophosphatidylserine lipase ABHD12 isoform 2
NM_001356550.1 NP_001343479.1 lysophosphatidylserine lipase ABHD12 isoform 3
NM_024465.3 NP_077785.2 lysophosphatidylserine lipase ABHD12 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lysophospholipase activity IDA
IDA: Inferred from direct assay
30237167 MGI
enables lysophospholipase activity IMP
IMP: Inferred from mutant phenotype
25580854 MGI
enables monoacylglycerol lipase activity IDA
IDA: Inferred from direct assay
18096503 MGI
enables palmitoyl-(protein) hydrolase activity IDA
IDA: Inferred from direct assay
27307232 MGI
Biological Process GO Annotation Evidence References Source
involved in acylglycerol catabolic process IDA
IDA: Inferred from direct assay
18096503 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
23297193 MGI
involved in monoacylglycerol catabolic process IDA
IDA: Inferred from direct assay
30237167 MGI
acts upstream of or within phosphatidylserine catabolic process IMP
IMP: Inferred from mutant phenotype
23297193 MGI
involved in phospholipid catabolic process IDA
IDA: Inferred from direct assay
30237167 MGI
involved in phospholipid catabolic process IMP
IMP: Inferred from mutant phenotype
25580854 MGI
involved in protein depalmitoylation IDA
IDA: Inferred from direct assay
27307232 MGI
involved in regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
30643283 MGI
acts upstream of or within response to auditory stimulus IMP
IMP: Inferred from mutant phenotype
23297193 MGI
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
22632720 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
27307232 MGI
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
27307232 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
30237167 MGI
located in membrane IDA
IDA: Inferred from direct assay
18096503 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysophosphatidylserine lipase ABHD12

  • 2-arachidonoylglycerol hydrolase ABHD12

  • abhydrolase domain-containing protein 12

  • monoacylglycerol lipase ABHD12

  • oxidized phosphatidylserine lipase ABHD12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114157 DO-264 Inhibitor 99.96% Unkown
HY-139174 (S)-DO271 / Unkown
HY-152152 JZP-MA-13 Inhibitor / Unkown
HY-RS00086 ABHD12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00087 ABHD12B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21811 Abhd12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28327 Abhd12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abhd12 NCBI NCBI:26090