2. Gene
  3. Ehmt1 - euchromatic histone methyltransferase 1 Gene

Ehmt1 - euchromatic histone methyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GLP; GLP1; KMT1D; mKIAA1876; D330003E03; Eu-HMTase1; 9230102N17Rik

Gene ID: 77683 | Gene type: protein coding

About Ehmt1

Chromosome 2: 24,679,940-24,809,626 reverse strand.GRCm39:CM000995.3

This gene has 18 transcripts (splice variants), 314 orthologues, 20 paralogues and is associated with 82 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 26.6), whole brain E14.5 (RPKM 23.) and 28 other tissues.

Summary

Enables C2H2 zinc finger domain binding activity; Histone Methyltransferase activity (H3-K27 specific); and Histone Methyltransferase activity (H3-K9 specific). Involved in several processes, including macromolecule methylation; negative regulation of transcription, DNA-templated; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; forelimb; integumental system; nervous system; and respiratory system. Used to study Kleefstra syndrome 1. Human ortholog(s) of this gene implicated in Kleefstra syndrome and Kleefstra syndrome 1. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ehmt1 Products(4)

mRNA Protein Name
NM_001012518.3 NP_001012536.2 histone-lysine N-methyltransferase EHMT1 isoform 1
NM_001109687.2 NP_001103157.1 histone-lysine N-methyltransferase EHMT1 isoform 4
NM_001109686.2 NP_001103156.1 histone-lysine N-methyltransferase EHMT1 isoform 3
NM_172545.4 NP_766133.2 histone-lysine N-methyltransferase EHMT1 isoform 2

Ehmt1 Protein Structure

EHMT_ZBD

EHMT_ZBD: cd20905 (506 - 636)

PHA03095

PHA03095: cl33707 (744 - 970)

ANK

ANK: sd00045 (764 - 793)

ANK

ANK: sd00045 (795 - 826)

Ank_2

Ank_2: pfam12796 (800 - 893)

ANK

ANK: sd00045 (828 - 860)

ANK

ANK: sd00045 (862 - 893)

ANK

ANK: sd00045 (895 - 926)

ANK

ANK: sd00045 (928 - 959)

SET_EHMT1

SET_EHMT1: cd10535 (1026 - 1256)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1289 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase EHMT1

G9a-like protein 1

euchromatic histone-lysine N-methyltransferase 1

lysine N-methyltransferase 1D

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12583 A-366 Inhibitor 98.02% Unkown
HY-13808 UNC 0631 Inhibitor 98.35% Unkown
HY-13807 UNC0646 Inhibitor 99.82% Unkown
HY-111904 EHMT2-IN-2 Inhibitor ≥99.0% Unkown
HY-111778 EHMT2-IN-1 Inhibitor 99.85% Unkown
HY-148817 WDR5-0102 Inhibitor 97.02% Unkown
HY-RS04227 EHMT1 Human Pre-designed siRNA Set A / Unkown
HY-RS04228 Ehmt1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04229 EHMT1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ehmt1 NCBI NCBI:79813