Ehmt1 - euchromatic histone methyltransferase 1 Gene

Also Known as GLP; GLP1; KMT1D; mKIAA1876; D330003E03; Eu-HMTase1; 9230102N17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77683

About Ehmt1

Chromosome 2: 24,679,940-24,809,626 reverse strand.GRCm39:CM000995.3

This gene has 18 transcripts (splice variants), 314 orthologues, 20 paralogues and is associated with 82 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 26.6), whole brain E14.5 (RPKM 23.) and 28 other tissues.

Summary

Enables C2H2 zinc finger domain binding activity; Histone Methyltransferase activity (H3-K27 specific); and Histone Methyltransferase activity (H3-K9 specific). Involved in several processes, including macromolecule methylation; negative regulation of transcription, DNA-templated; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; forelimb; integumental system; nervous system; and respiratory system. Used to study Kleefstra syndrome 1. Human ortholog(s) of this gene implicated in Kleefstra syndrome and Kleefstra syndrome 1. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ehmt1 Products (4)

mRNA Protein Name
NM_001012518.3 NP_001012536.2 histone-lysine N-methyltransferase EHMT1 isoform 1
NM_001109687.2 NP_001103157.1 histone-lysine N-methyltransferase EHMT1 isoform 4
NM_001109686.2 NP_001103156.1 histone-lysine N-methyltransferase EHMT1 isoform 3
NM_172545.4 NP_766133.2 histone-lysine N-methyltransferase EHMT1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables C2H2 zinc finger domain binding IPI
IPI: Inferred from physical interaction
16702210 MGI
enables histone H3K27 methyltransferase activity IDA
IDA: Inferred from direct assay
15774718 MGI
enables histone H3K9 methyltransferase activity IDA
IDA: Inferred from direct assay
15774718 MGI
enables histone H3K9 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
18818694 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15774718 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA methylation-dependent heterochromatin formation IDA
IDA: Inferred from direct assay
18818694 MGI
involved in facultative heterochromatin formation IDA
IDA: Inferred from direct assay
19010785 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
21131967 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17392792 MGI
involved in peptidyl-lysine dimethylation IMP
IMP: Inferred from mutant phenotype
15774718 MGI
involved in peptidyl-lysine monomethylation IMP
IMP: Inferred from mutant phenotype
15774718 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
24196706 MGI
involved in regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
15774718 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15774718 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ehmt1 Protein Structure

EHMT_ZBD

EHMT_ZBD: cd20905 (506 - 636)

PHA03095

PHA03095: cl33707 (744 - 970)

ANK

ANK: sd00045 (764 - 793)

ANK

ANK: sd00045 (795 - 826)

Ank_2

Ank_2: pfam12796 (800 - 893)

ANK

ANK: sd00045 (828 - 860)

ANK

ANK: sd00045 (862 - 893)

ANK

ANK: sd00045 (895 - 926)

ANK

ANK: sd00045 (928 - 959)

SET_EHMT1

SET_EHMT1: cd10535 (1026 - 1256)

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  • 1289 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase EHMT1

  • G9a-like protein 1

  • euchromatic histone-lysine N-methyltransferase 1

  • lysine N-methyltransferase 1D

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15273 UNC0638 99.84% Unkown
HY-12583 A-366 Inhibitor 98.13% Unkown
HY-13808 UNC 0631 Inhibitor 99.27% Unkown
HY-111778 EHMT2-IN-1 Inhibitor 99.85% Unkown
HY-13807 UNC0646 Inhibitor 99.38% Unkown
HY-161759 MS152 Inhibitor 99.36% Unkown
HY-111904 EHMT2-IN-2 Inhibitor 99.0% Unkown
HY-13808R UNC 0631 (Standard) Inhibitor 99.54% Unkown
HY-RS04227 EHMT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04228 Ehmt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04229 EHMT1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-110093 UNC0638 hydrate Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ehmt1 NCBI NCBI:79813