Polq - polymerase (DNA directed), theta Gene

Also Known as A430110D14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77782

Summary

Enables DNA-directed DNA Polymerase activity. Involved in double-strand break repair via alternative nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and somatic hypermutation of immunoglobulin genes. Acts upstream of or within DNA repair. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Is expressed in embryo; heart; spleen; and testis. Orthologous to human POLQ (DNA Polymerase theta). [provided by Alliance of Genome Resources, Apr 2022]

Polq Products (2)

mRNA Protein Name
NM_001159369.1 NP_001152841.1 DNA polymerase theta isoform 2
NM_029977.2 NP_084253.1 DNA polymerase theta isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA helicase activity IDA
IDA: Inferred from direct assay
29058711 MGI
enables DNA-directed DNA polymerase activity IDA
IDA: Inferred from direct assay
29058711 MGI
enables DNA-directed DNA polymerase activity IMP
IMP: Inferred from mutant phenotype
25642960 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA repair IGI
IGI: Inferred from genetic interaction
15542845 MGI
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
12663541 MGI
involved in double-strand break repair via alternative nonhomologous end joining IDA
IDA: Inferred from direct assay
25642960 MGI
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
25642960 MGI
involved in negative regulation of double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
28687761 MGI
involved in somatic hypermutation of immunoglobulin genes IMP
IMP: Inferred from mutant phenotype
16172387 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA polymerase theta

  • DNA polymerase eta

  • chromosome aberrations occurring spontaneously protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10836 POLQ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183630 AZD4956 Inhibitor / Unkown
HY-182322 POLQ-IN-1 Inhibitor / Unkown
HY-RS10833 POLK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17891 Polq Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24360 Polq Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Polq NCBI NCBI:10721