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Art. -Nr.: HY-182322

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POLQ-IN-1

POLQ-IN-1 is a DNA polymerase θ (POLQ) inhibitor with a pIC₅₀ of 8.2. POLQ-IN-1 inhibits the proliferation of homologous recombination-deficient cells. POLQ-IN-1 is used for the research of homologous recombination-deficient tumors.

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CAS. Nr.: 3109024-27-0
Formel: C₂₈H₂₆ClF₃N₄O₅
Molecular Weight:590.98

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

POLQ-IN-1 Chemical Structure

CAS. Nr.: 3109024-27-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

POLQ-IN-1 (Compound 9) inhibits the proliferation of BRCA2-deficient cells with a pIC₅₀ of 6.2^[1].
POLQ-IN-1 exhibits only extremely low antiproliferative activity in DLD1 cells, with a pIC₅₀ value of <5.0^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3109024-27-0
Molecular Weight 590.98
Formel C₂₈H₂₆ClF₃N₄O₅
SMILES

O=C(C(CCOC1=CC(Cl)=C(C2=NC3=C(N2CC4=CC(OC(F)(F)F)=CC=C4)N=CN=C3OC5(CC5)C)C=C1)C)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Bazan Russo TD, et al. Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumors. Cancer Gene Ther. 2024 Nov;31(11):1619-1631.
[Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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POLQ-IN-1

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

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POLQ-IN-1 Related Classifications

HY-182322 Related Classifications