2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. POLQ-IN-1

POLQ-IN-1 is a DNA polymerase θ (POLQ) inhibitor with a pIC50 of 8.2. POLQ-IN-1 inhibits the proliferation of homologous recombination-deficient cells. POLQ-IN-1 is used for the research of homologous recombination-deficient tumors.

For research use only. We do not sell to patients.

POLQ-IN-1

POLQ-IN-1 Chemical Structure

CAS No. : 3109024-27-0

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POLQ-IN-1 Related Antibodies

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Description

POLQ-IN-1 is a DNA polymerase θ (POLQ) inhibitor with a pIC50 of 8.2. POLQ-IN-1 inhibits the proliferation of homologous recombination-deficient cells. POLQ-IN-1 is used for the research of homologous recombination-deficient tumors[1].

In Vitro

POLQ-IN-1 (Compound 9) inhibits the proliferation of BRCA2-deficient cells with a pIC50 of 6.2[1].
POLQ-IN-1 exhibits only extremely low antiproliferative activity in DLD1 cells, with a pIC50 value of <5.0[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

POLQ-IN-1 Related Antibodies
Molecular Weight

590.98

Formula

C28H26ClF3N4O5
CAS No.
SMILES

O=C(C(CCOC1=CC(Cl)=C(C2=NC3=C(N2CC4=CC(OC(F)(F)F)=CC=C4)N=CN=C3OC5(CC5)C)C=C1)C)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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POLQ-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

POLQ-IN-13109024-27-0DNA/RNA SynthesisPOLQ polymerase domainDLD1 cellsHR-deficient cellsDNA polymerase thetaBRCA2-deficient cellsHR-deficient tumorsBRCA2 -/- cellsInhibitorinhibitorinhibit

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POLQ-IN-1
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HY-182322
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