Six3 - SIX homeobox 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 78974

Summary

Enables signaling receptor binding activity. Involved in negative regulation of transcription, DNA-templated. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Six3 Products (1)

mRNA Protein Name
NM_023990.2 NP_076480.1 homeobox protein SIX3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables signaling receptor binding IMP
IMP: Inferred from mutant phenotype
12493766 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12493766 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein SIX3

  • sine oculis homeobox homolog 3

  • sine oculis-related homeobox 3 homolog

Six3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Six3 Q9ET75 Mta1 Rattus norvegicus Q62599
Anti Bait CoIP
17666527
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12960 SIX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21433 Six3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27951 Six3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Six3 NCBI NCBI:6496