GID4 - GID complex subunit 4 homolog Gene

Also Known as VID2; VID24; C17orf39

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79018

About GID4

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,039,408-18,068,405 (from NCBI)

This gene has 5 transcripts (splice variants) and 260 orthologues. Broad expression in testis (RPKM 9.8), esophagus (RPKM 5.1) and 25 other tissues.

Summary

The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GID4 Products (2)

mRNA Protein Name
NM_001411057.1 NP_001397986.1 glucose-induced degradation protein 4 homolog isoform 2
NM_024052.5 NP_076957.3 glucose-induced degradation protein 4 homolog isoform 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
29911972 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GID4 Protein Structure

Vac_ImportDeg

Vac_ImportDeg: Vacuolar import and degradation protein (121 - 289)

  • 0
  • 100
  • 200
  • 300 a.a.
Protein Preferred Names Protein Names

glucose-induced degradation protein 4 homolog

  • GID complex subunit 4, VID24 homolog

Related Diseases

Diseases Alias
Smith-Magenis Syndrome

  • SMS

  • Chromosome 17p11.2 Deletion Syndrome

  • 17p11.2 Microdeletion Syndrome

  • 17p11.2 Monosomy

  • Chromosome 17p Deletion Syndrome

  • Del(17)

  • P11.2

  • 17p- Syndrome

  • Deletion 17p Syndrome

  • Partial Monosomy 17p
Malignant Giant Cell Tumor

  • Malignant Tumor, Giant Cell Type

  • Malignant Giant Cell Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150908 Brigatinib A Ligand / Unkown
HY-151475 GID4 Ligand 1 / Unkown
HY-151476 GID4 Ligand 2 / Unkown
HY-151479 GID4 Ligand 3 / Unkown
HY-163576 GID4-IN-1 Inhibitor / Unkown
HY-174368 PROTAC EML4-ALK Degrader-1 / Unkown
HY-174996 NEP162 / Unkown
HY-174997 PFI-7-O-C4-piperazin / Unkown
HY-180957 NEP108 Degrader / Unkown
HY-180959 NEP168 Degrader / Unkown
HY-180960 NEP202 Degrader / Unkown
HY-184923 PROTAC BRD4 Degrader-48 Degrader / Unkown
HY-D2259 PFI-7 / Unkown
HY-RS05419 GID4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18937 Gid4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25427 Gid4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GID4 MGD MGI:1914021
Macaca mulatta GID4 VGNC VGNC:104604
Rattus norvegicus GID4 RGD RGD:1588894
Bos taurus GID4 VGNC VGNC:55833
Canis familiaris GID4 VGNC VGNC:49858
Felis catus GID4 VGNC VGNC:62549
Others GID4 NCBI