PDCL3 - phosducin like 3 Gene

Also Known as VIAF; PHLP3; VIAF1; HTPHLP; PHLP2A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79031

About PDCL3

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:100,562,993-100,576,739 (from NCBI)

This gene has 3 transcripts (splice variants), 222 orthologues and 4 paralogues. Ubiquitous expression in appendix (RPKM 9.1), esophagus (RPKM 8.2) and 25 other tissues.

Summary

This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

PDCL3 Products (1)

mRNA	Protein	Name
NM_024065.5	NP_076970.1	phosducin-like protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15371430	GOA
enables protein folding chaperone	IMP IMP: Inferred from mutant phenotype	26059764	GOA
enables protein folding chaperone	IPI IPI: Inferred from physical interaction	23792958	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17429077	GOA
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	26059764	GOA
involved in chaperone-mediated protein folding	IMP IMP: Inferred from mutant phenotype	26059764	GOA
involved in negative regulation of chaperone-mediated protein folding	IMP IMP: Inferred from mutant phenotype	17429077	GOA
acts upstream of or within negative regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	23792958	GOA
acts upstream of or within positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	23792958	GOA
acts upstream of or within positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	23792958	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26059764	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	26059764	GOA
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	23792958	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15371430	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	26059764	GOA
located in perinucleolar compartment	IDA IDA: Inferred from direct assay	26059764	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCL3 Protein Structure

Phosducin

0
100
200
239 a.a.

Protein Preferred Names	Protein Names
phosducin-like protein 3	IAP-associated factor VIAF1

PDCL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDCL3	Q9H2J4	ACTRT3	Homo sapiens	Q9BYD9	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1	Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome Berdon Syndrome MMIHS Megacystis Microcolon Intestinal Hypoperistalsis Syndrome Megacystis, Microcolon, Hypoperistalsis Syndrome Visceral Myopathy Mmih Syndrome Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome MMIHS1 Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih Mmhs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10198	PDCL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PDCL3	VGNC	VGNC:44344
Rattus norvegicus	PDCL3	RGD	RGD:1309663
Mus musculus	PDCL3	MGD	MGI:1916083
Bos taurus	PDCL3	VGNC	VGNC:32667
Others	PDCL3	NCBI