Hes5 - hes family bHLH transcription factor 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 79225

Summary

Enables chromatin binding activity and double-stranded DNA binding activity. Involved in several processes, including generation of neurons; negative regulation of cell differentiation; and neuronal stem cell population maintenance. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human HES5 (hes family bHLH transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Hes5 Products (1)

mRNA Protein Name
NM_024383.1 NP_077359.1 transcription factor HES-5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
17006542 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
1400497 RGD
Biological Process GO Annotation Evidence References Source
involved in forebrain radial glial cell differentiation IDA
IDA: Inferred from direct assay
11399758 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
1400497 RGD
involved in negative regulation of forebrain neuron differentiation IDA
IDA: Inferred from direct assay
11399758 RGD
involved in negative regulation of pro-B cell differentiation IMP
IMP: Inferred from mutant phenotype
12032823 RGD
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17006542 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12032823 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
1400497 RGD
involved in neuronal stem cell population maintenance IDA
IDA: Inferred from direct assay
11399758 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor HES-5

  • hairy and enhancer of split 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120782 Yhhu-3792 Activator 99.34% Unkown
HY-120782A Yhhu-3792 hydrochloride Activator / Unkown
HY-172528 Enpp-1/3-IN-1 Inhibitor / Unkown
HY-RS06138 HES5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18944 Hes5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25434 Hes5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hes5 NCBI NCBI:388585