Txn2 - thioredoxin 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 79462

Summary

Contributes to peptide-methionine (R)-S-oxide reductase activity; peptide-methionine (S)-S-oxide reductase activity; and protein-disulfide reductase activity. Involved in several processes, including response to axon injury; response to glucose; and response to hypoxia. Located in dendrite; mitochondrion; and neuronal cell body. Human ortholog(s) of this gene implicated in combined Oxidative Phosphorylation deficiency 29. Orthologous to human TXN2 (thioredoxin 2). [provided by Alliance of Genome Resources, Apr 2022]

Txn2 Products (1)

mRNA Protein Name
NM_053331.2 NP_445783.1 thioredoxin, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to peptide-methionine (R)-S-oxide reductase activity IDA
IDA: Inferred from direct assay
18452709 RGD
contributes to peptide-methionine (S)-S-oxide reductase activity IDA
IDA: Inferred from direct assay
18452709 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16774913 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
18452709 RGD
contributes to protein-disulfide reductase activity IDA
IDA: Inferred from direct assay
9006939 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to nutrient levels IEP
IEP: Inferred from expression pattern
18578693 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
18441302 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
15039483 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
10792444 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15468176 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18790005 RGD
involved in response to oxidative stress IEP
IEP: Inferred from expression pattern
18441302 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17253623 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
20620191 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20620191 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thioredoxin, mitochondrial

  • MTRX

  • mt-Trx

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15288 TXN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19392 Txn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25884 Txn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Txn2 NCBI NCBI:25828