TXN2 - thioredoxin 2 Gene

Homo sapiens

Also known as TXN; MTRX; TRX2; MT-TRX; COXPD29

Gene ID: 25828 | Gene type: protein coding

About TXN2

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,467,046-36,481,640 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 39.7), kidney (RPKM 28.5) and 25 other tissues.

Summary

This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced Apoptosis. [provided by RefSeq, Jul 2008]

TXN2 Products(1)

mRNA	Protein	Name
NM_012473.4	NP_036605.2	thioredoxin, mitochondrial precursor

TXN2 Protein Structure

Thioredoxin

0
100
166 a.a.

Protein Preferred Names

Protein Names

thioredoxin, mitochondrial

mitochondrial thioredoxin

Recombinant TXN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71393	TXN2 Protein, Human (His)	Q99757 (T60-G166)	≥95%

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 29

COXPD29

Combined Oxidative Phosphorylation Defect Type 29

Ocular Hypertension

Hypertension, Ocular	Intraocular Pressure Increase
Oh - [Ocular Hypertension]	Oht - [Ocular Hypertension]

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15288	TXN2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TXN2	RGD	RGD:71040
Canis familiaris	TXN2	VGNC	VGNC:48009
Bos taurus	TXN2	VGNC	VGNC:36533
Felis catus	TXN2	VGNC	VGNC:66723
Mus musculus	TXN2	MGD	MGI:1929468
Others	TXN2	NCBI