TXN2 - thioredoxin 2 Gene

Also Known as TXN; MTRX; TRX2; MT-TRX; COXPD29

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25828

About TXN2

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,467,046-36,481,640 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 39.7), kidney (RPKM 28.5) and 25 other tissues.

Summary

This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced Apoptosis. [provided by RefSeq, Jul 2008]

TXN2 Products (1)

mRNA Protein Name
NM_012473.4 NP_036605.2 thioredoxin, mitochondrial precursor

TXN2 Protein Structure

Thioredoxin

Thioredoxin: Thioredoxin (69 - 163)

  • 0
  • 100
  • 166 a.a.
Protein Preferred Names Protein Names

thioredoxin, mitochondrial

  • mitochondrial thioredoxin

TXN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TXN2 Q99757 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
TXN2 Q99757 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
TXN2 Q99757 ODAD1 Homo sapiens Q96M63
Y2H Array
25416956
Intra
TXN2 Q99757 ODAD1 Homo sapiens Q96M63
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
TXN2 Q99757 ZBTB14 Homo sapiens O43829
Validated Y2H
25416956
Intra
TXN2 Q99757 ZBTB14 Homo sapiens O43829
Y2H Array
25416956
Intra
TXN2 Q99757 ZBTB14 Homo sapiens O43829
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 MAGEA11 Homo sapiens P43364-2
Validated Y2H
25416956
Intra
TXN2 Q99757 q6zn96_human Homo sapiens Q6ZN96
Y2H Array
32296183
Intra
TXN2 Q99757 q6zn96_human Homo sapiens Q6ZN96
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 PPP1R16B Homo sapiens Q96T49
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 PPP1R16B Homo sapiens Q96T49
Y2H Array
32296183
Intra
TXN2 Q99757 BCAS2 Homo sapiens O75934
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 BCAS2 Homo sapiens O75934
Y2H Array
32296183
Intra
TXN2 Q99757 UQCC2 Homo sapiens Q9BRT2
Validated Y2H
32296183
Intra
TXN2 Q99757 UQCC2 Homo sapiens Q9BRT2
Y2H Array
32296183
Intra
TXN2 Q99757 UQCC2 Homo sapiens Q9BRT2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 CHMP1A Homo sapiens Q9HD42
Validated Y2H
32296183
Intra
TXN2 Q99757 CHMP1A Homo sapiens Q9HD42
Y2H Array
32296183
Intra
TXN2 Q99757 CHMP1A Homo sapiens Q9HD42
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MAGEB2 Homo sapiens O15479
Y2H Array
32296183
Intra
TXN2 Q99757 MAGEB2 Homo sapiens O15479
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 RBM45 Homo sapiens Q8IUH3-3
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 RBM45 Homo sapiens Q8IUH3-3
Y2H Array
32296183
Intra
TXN2 Q99757 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
TXN2 Q99757 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
TXN2 Q99757 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra
TXN2 Q99757 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
TXN2 Q99757 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
Intra
TXN2 Q99757 AP2B1 Homo sapiens P63010-2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 AP2B1 Homo sapiens P63010-2
Y2H Array
32296183
Intra
TXN2 Q99757 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra
TXN2 Q99757 SCYL3 Homo sapiens Q8IZE3-2
Y2H Array
32296183
Intra
TXN2 Q99757 SCYL3 Homo sapiens Q8IZE3-2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 GUCD1 Homo sapiens Q96NT3-2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 GUCD1 Homo sapiens Q96NT3-2
Y2H Array
32296183
Intra
TXN2 Q99757 CRACR2B Homo sapiens Q8N4Y2-3
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 CRACR2B Homo sapiens Q8N4Y2-3
Y2H Array
32296183
Intra
TXN2 Q99757 KAZN Homo sapiens Q674X7-2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 KAZN Homo sapiens Q674X7-2
Y2H Array
32296183
Intra
TXN2 Q99757 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
TXN2 Q99757 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
TXN2 Q99757 ANKRD36B Homo sapiens Q8N2N9-4
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 ANKRD36B Homo sapiens Q8N2N9-4
Y2H Array
32296183
Intra
TXN2 Q99757 POMC Homo sapiens P01189
Y2H Array
32296183
Intra
TXN2 Q99757 POMC Homo sapiens P01189
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 CIB4 Homo sapiens A0PJX0
Y2H Array
32296183
Intra
TXN2 Q99757 CIB4 Homo sapiens A0PJX0
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MYL9 Homo sapiens P24844-2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MYL9 Homo sapiens P24844-2
Y2H Array
32296183
Intra
TXN2 Q99757 CSTPP1 Homo sapiens Q9H6J7-2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 CSTPP1 Homo sapiens Q9H6J7-2
Validated Y2H
32296183
Intra
TXN2 Q99757 CSTPP1 Homo sapiens Q9H6J7-2
Y2H Array
32296183
Intra
TXN2 Q99757 SCYL3 Homo sapiens Q8IZE3
Y2H Array
31515488
Intra
TXN2 Q99757 REEP6 Homo sapiens Q96HR9-2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 REEP6 Homo sapiens Q96HR9-2
Y2H Array
32296183
Intra
TXN2 Q99757 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
TXN2 Q99757 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 CDCA4 Homo sapiens Q9BXL8
Validated Y2H
32296183
Intra
TXN2 Q99757 CDCA4 Homo sapiens Q9BXL8
Y2H Array
32296183
Intra
TXN2 Q99757 CDCA4 Homo sapiens Q9BXL8
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 RBM45 Homo sapiens Q8IUH3
Y2H Array
25416956
Intra
TXN2 Q99757 RBM45 Homo sapiens Q8IUH3
Validated Y2H
25416956
Intra
TXN2 Q99757 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 SSNA1 Homo sapiens O43805
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 SSNA1 Homo sapiens O43805
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 SSNA1 Homo sapiens O43805
Y2H Array
25416956
Intra
TXN2 Q99757 SSNA1 Homo sapiens O43805
Y2H Array
32296183
Intra
TXN2 Q99757 MIPOL1 Homo sapiens Q8TD10
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MIPOL1 Homo sapiens Q8TD10
Y2H Array
32296183
Intra
TXN2 Q99757 HAUS8 Homo sapiens Q9BT25
Y2H Array
32296183
Intra
TXN2 Q99757 HAUS8 Homo sapiens Q9BT25
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 HAUS8 Homo sapiens Q9BT25
Validated Y2H
32296183
Intra
TXN2 Q99757 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
Intra
TXN2 Q99757 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra
TXN2 Q99757 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
TXN2 Q99757 PSME3 Homo sapiens P61289
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 PSME3 Homo sapiens P61289
Validated Y2H
25416956
Intra
TXN2 Q99757 STUB1 Homo sapiens Q9UNE7
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 STUB1 Homo sapiens Q9UNE7
Validated Y2H
25416956
Intra
TXN2 Q99757 SPTA1 Homo sapiens P02549
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 SPTA1 Homo sapiens P02549
Y2H Array
32296183
Intra
TXN2 Q99757 AP2B1 Homo sapiens P63010
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 AP2B1 Homo sapiens P63010
Validated Y2H
25416956
Intra
TXN2 Q99757 GPRASP2 Homo sapiens Q96D09
Y2H
21988832
Intra
TXN2 Q99757 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
Intra
TXN2 Q99757 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
TXN2 Q99757 PEX19 Homo sapiens P40855
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 PEX19 Homo sapiens P40855
Y2H Array
32296183
Intra
TXN2 Q99757 GTPBP2 Homo sapiens Q9BX10
Validated Y2H
32296183
Intra
TXN2 Q99757 GTPBP2 Homo sapiens Q9BX10
Y2H Array
32296183
Intra
TXN2 Q99757 GTPBP2 Homo sapiens Q9BX10
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 SYCE1 Homo sapiens Q8N0S2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 SYCE1 Homo sapiens Q8N0S2
Y2H Array
32296183
Intra
TXN2 Q99757 SAT1 Homo sapiens P21673
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 SAT1 Homo sapiens P21673
Y2H Array
32296183
Intra
TXN2 Q99757 ETHE1 Homo sapiens O95571
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 ETHE1 Homo sapiens O95571
Y2H Array
32296183
Intra
TXN2 Q99757 CGGBP1 Homo sapiens Q9UFW8
Validated Y2H
32296183
Intra
TXN2 Q99757 CGGBP1 Homo sapiens Q9UFW8
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 CGGBP1 Homo sapiens Q9UFW8
Y2H Array
32296183
Intra
TXN2 Q99757 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
TXN2 Q99757 PPCDC Homo sapiens Q96CD2
Y2H Array
32296183
Intra
TXN2 Q99757 PPCDC Homo sapiens Q96CD2
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MAPRE3 Homo sapiens Q9UPY8
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
25416956
Intra
TXN2 Q99757 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
Intra
TXN2 Q99757 MAPRE3 Homo sapiens Q9UPY8
Y2H Array
32296183
Intra
TXN2 Q99757 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
TXN2 Q99757 MAPRE2 Homo sapiens Q15555
Validated Y2H
25416956
Intra
TXN2 Q99757 MAPRE2 Homo sapiens Q15555
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MAPRE2 Homo sapiens Q15555
Y2H Array
25416956
Intra
TXN2 Q99757 MAPRE2 Homo sapiens Q15555
Y2H Array
32296183
Intra
TXN2 Q99757 TIFA Homo sapiens Q96CG3
Y2H Array
25416956
Intra
TXN2 Q99757 ABI3 Homo sapiens Q9P2A4
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra
TXN2 Q99757 ABI3 Homo sapiens Q9P2A4
Y2H Array
32296183
Intra
TXN2 Q99757 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
Intra
TXN2 Q99757 DDIT3 Homo sapiens P35638
Y2H Array
32296183
Intra
TXN2 Q99757 DDIT3 Homo sapiens P35638
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
Intra
TXN2 Q99757 MAGEA4 Homo sapiens P43358
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MAGEA4 Homo sapiens P43358
Y2H Array
32296183
Intra
TXN2 Q99757 RPIA Homo sapiens P49247
Y2H Array
25416956
Intra
TXN2 Q99757 RPIA Homo sapiens P49247
Y2H Array
32296183
Intra
TXN2 Q99757 RPIA Homo sapiens P49247
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 RPIA Homo sapiens P49247
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 STN1 Homo sapiens Q9H668
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 STN1 Homo sapiens Q9H668
Validated Y2H
32296183
Intra
TXN2 Q99757 STN1 Homo sapiens Q9H668
Y2H Array
32296183
Intra
TXN2 Q99757 MRFAP1L1 Homo sapiens Q96HT8
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 MRFAP1L1 Homo sapiens Q96HT8
Validated Y2H
25416956
Intra
TXN2 Q99757 MRFAP1L1 Homo sapiens Q96HT8
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MRFAP1L1 Homo sapiens Q96HT8
Y2H Array
25416956
Intra
TXN2 Q99757 MRFAP1L1 Homo sapiens Q96HT8
Y2H Array
32296183
Intra
TXN2 Q99757 REEP6 Homo sapiens Q96HR9
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 REEP6 Homo sapiens Q96HR9
Validated Y2H
25416956
Intra
TXN2 Q99757 REEP6 Homo sapiens Q96HR9
Y2H Array
25416956
Intra
TXN2 Q99757 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra
TXN2 Q99757 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 CCDC197 Homo sapiens Q8NCU1
Y2H Array
32296183
Intra
TXN2 Q99757 CCDC197 Homo sapiens Q8NCU1
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 TRIM21 Homo sapiens P19474
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 TRIM21 Homo sapiens P19474
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 TRIM21 Homo sapiens P19474
Y2H Array
32296183
Intra
TXN2 Q99757 TRIM21 Homo sapiens P19474
Validated Y2H
25416956
Intra
TXN2 Q99757 TTC32 Homo sapiens Q5I0X7
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 TTC32 Homo sapiens Q5I0X7
Y2H Array
32296183
Intra
TXN2 Q99757 RABGEF1 Homo sapiens Q9UJ41
Y2H Prey Pooling
25416956
Intra
TXN2 Q99757 TMOD4 Homo sapiens Q9NZQ9
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 TMOD4 Homo sapiens Q9NZQ9
Validated Y2H
32296183
Intra
TXN2 Q99757 TMOD4 Homo sapiens Q9NZQ9
Y2H Array
32296183
Intra
TXN2 Q99757 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Intra
TXN2 Q99757 MRFAP1 Homo sapiens Q9Y605
Y2H Prey Pooling
32296183
Intra
TXN2 Q99757 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TXN2 Proteins

Cat. No. Product Name Accession Purity
HY-P71393 TXN2 Protein, Human Q99757 (T60-G166) ≥ 95%, as determined by reducing SDS-PAGE.

TXN2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82447 Thioredoxin 2 Antibody (YA2192) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P82447A Thioredoxin 2 Antibody (YA2192)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 29

  • COXPD29

  • Combined Oxidative Phosphorylation Defect Type 29
Ocular Hypertension

  • Hypertension, Ocular

  • Intraocular Pressure Increase

  • Oh - [Ocular Hypertension]

  • Oht - [Ocular Hypertension]
Dystonia

  • Dystonic Disease

  • Dystonic Disorder

  • Dystonia Disorders

  • Neuroleptic Dyskinesia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15288 TXN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19392 Txn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25884 Txn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TXN2 RGD RGD:71040
Canis familiaris TXN2 VGNC VGNC:48009
Bos taurus TXN2 VGNC VGNC:36533
Felis catus TXN2 VGNC VGNC:66723
Mus musculus TXN2 MGD MGI:1929468
Others TXN2 NCBI