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MAGEB2 - MAGE family member B2 Gene

Also Known as DAM6; CT3.2; MAGE-XP-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4113

About MAGEB2

Cytogenetic location: Xp21.2 Genomic coordinates (GRCh38): X:30,215,563-30,220,089 (from NCBI)

This gene has 1 transcript (splice variant), 280 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 20.5).

Summary

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each Other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]

MAGEB2 Products (1)

mRNA	Protein	Name
NM_002364.5	NP_002355.2	melanoma-associated antigen B2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGEB2 Protein Structure

MAGE_N

MAGE

0
100
200
300
319 a.a.

Protein Preferred Names	Protein Names
melanoma-associated antigen B2	DSS/AHC critical interval MAGE superfamily 6

MAGEB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAGEB2	O15479	RPGRIP1	Homo sapiens	Q96KN7	Y2H Prey Pooling	25416956
Intra	MAGEB2	O15479	CCNL2	Homo sapiens	Q96S94-5	Y2H Array	32296183
Intra	MAGEB2	O15479	CCNL2	Homo sapiens	Q96S94-5	Y2H Prey Pooling	32296183
Intra	MAGEB2	O15479	CCNL2	Homo sapiens	Q96S94-5	Validated Y2H	32296183
Intra	MAGEB2	O15479	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	MAGEB2	O15479	FUS	Homo sapiens	P35637	Validated Y2H	32814053
Intra	MAGEB2	O15479	FUS	Homo sapiens	P35637	Y2H Pooling	32814053
Intra	MAGEB2	O15479	FUS	Homo sapiens	P35637	Anti Bait CoIP	17353931
Intra	MAGEB2	O15479	FUS	Homo sapiens	P35637	Y2H Array	32814053
Intra	MAGEB2	O15479	ARID3A	Homo sapiens	Q99856	Y2H Prey Pooling	32296183
Intra	MAGEB2	O15479	ARID3A	Homo sapiens	Q99856	Y2H Array	32296183
Intra	MAGEB2	O15479	ARID3A	Homo sapiens	Q99856	Validated Y2H	32296183
Intra	MAGEB2	O15479	ECSIT	Homo sapiens	Q9BQ95	Validated Y2H	32296183
Intra	MAGEB2	O15479	ZBED1	Homo sapiens	O96006	Y2H Prey Pooling	32296183
Intra	MAGEB2	O15479	ZBED1	Homo sapiens	O96006	Validated Y2H	32296183
Intra	MAGEB2	O15479	ZBED1	Homo sapiens	O96006	Y2H Array	32296183
Intra	MAGEB2	O15479	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	MAGEB2	O15479	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	MAGEB2	O15479	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
46,Xy Sex Reversal	Swyer Syndrome Pure Gonadal Dysgenesis 46,Xy Gonadal Dysgenesis, Xy Female Type Gonadal Dysgenesis, 46,Xy 46,Xy Cgd 46,Xy Complete Gonadal Dysgenesis 46,Xy Pure Gonadal Dysgenesis 46 Xy Gonadal Dysgenesis 46, Xy Cgd 46, Xy Complete Gonadal Dysgenesis 46, Xy Pure Gonadal Dysgenesis Xy Pure Gonadal Dysgenesis Female With 46,Xy Karyotype Xy Females

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07971	MAGEB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAGEB2	RGD	RGD:1560904
Macaca mulatta	MAGEB2	VGNC	VGNC:74477
Mus musculus	MAGEB2	MGD	MGI:2148568
Others	MAGEB2	NCBI