MMRN2 - multimerin 2 Gene

Also Known as EMILIN3; EMILIN-3; ENDOGLYX-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79812

About MMRN2

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:86,935,540-86,957,615 (from NCBI)

This gene has 7 transcripts (splice variants), 183 orthologues and 4 paralogues. Broad expression in fat (RPKM 74.6), placenta (RPKM 22.4) and 20 other tissues.

Summary

This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]

MMRN2 Products (1)

mRNA Protein Name
NM_024756.3 NP_079032.2 multimerin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22020326 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
28671670 GOA
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IDA
IDA: Inferred from direct assay
31138217 GOA
involved in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
IDA: Inferred from direct assay
25745997 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
22020326 GOA
involved in negative regulation of cell migration involved in sprouting angiogenesis IDA
IDA: Inferred from direct assay
22020326 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
22020326 GOA
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
22020326 GOA
involved in positive regulation of epithelial tube formation IDA
IDA: Inferred from direct assay
25745997 GOA
involved in positive regulation of morphogenesis of an epithelium IDA
IDA: Inferred from direct assay
25745997 GOA
Cellular Component GO Annotation Evidence References Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
23979707 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
11559704 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMRN2 Protein Structure

EMI

EMI: EMI domain (54 - 128)

C1q

C1q: C1q domain (827 - 946)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 949 a.a.
Protein Preferred Names Protein Names

multimerin-2

  • EMILIN-like protein EndoGlyx-1

MMRN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MMRN2 Q9H8L6 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra
MMRN2 Q9H8L6 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

MMRN2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89600 Multimerin-2 Antibody (YA8944) IP, ICC/IF, IF-Tissue, FC human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08561 MMRN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MMRN2 MGD MGI:2385618
Canis familiaris MMRN2 VGNC VGNC:43292
Felis catus MMRN2 VGNC VGNC:63540
Macaca mulatta MMRN2 VGNC VGNC:74797
Rattus norvegicus MMRN2 RGD RGD:1311461
Bos taurus MMRN2 VGNC VGNC:31533
Others MMRN2 NCBI