NAA40 - N-alpha-acetyltransferase 40, NatD catalytic subunit Gene

Also Known as NatD; NAT11; PATT1; hNatD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79829

About NAA40

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,939,002-63,957,319 (from NCBI)

This gene has 10 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in testis (RPKM 9.3), spleen (RPKM 7.5) and 25 other tissues.

Summary

Enables H2A Histone Acetyltransferase activity; H4 Histone Acetyltransferase activity; and peptide-serine-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation; histone H2A acetylation; and histone H4 acetylation. Located in centriolar satellite; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NAA40 Products (2)

mRNA Protein Name
NM_001300800.1 NP_001287729.1 N-alpha-acetyltransferase 40 isoform 2
NM_024771.4 NP_079047.2 N-alpha-acetyltransferase 40 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables histone H2A acetyltransferase activity IDA
IDA: Inferred from direct assay
25619998 GOA
enables histone H4 acetyltransferase activity IDA
IDA: Inferred from direct assay
25619998 GOA
enables peptide-serine-alpha-N-acetyltransferase activity IDA
IDA: Inferred from direct assay
25619998 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25619998 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA40 Protein Structure

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (118 - 190)

  • 0
  • 100
  • 200
  • 237 a.a.
Protein Preferred Names Protein Names

N-alpha-acetyltransferase 40

  • N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog

Related Diseases

Diseases Alias
Pulmonary Subvalvular Stenosis

  • Pulmonary Infundibular Stenosis

  • Congenital Infundibular Stenosis

  • Infundibular Pulmonic Stenosis

  • Infundibular Pulmonic Stenosis, Congenital

  • Subvalvular Pulmonic Stenosis
Microphthalmia, Syndromic 1

  • MCOPS1

  • Lenz Microphthalmia Syndrome

  • Lenz Dysplasia

  • Mcops4

  • Syndromic Microphthalmia 1

  • Lenz Microphthalmia

  • Maa

  • Microphthalmia Or Anophthalmos With Associated Anomalies

  • Syndromic Microphthalmia Type 4

  • Microphthalmia, Syndromic 4

  • Microphthalmia, Syndromic 4, Formerly

  • Mcops4, Formerly

  • Anop1, Formerly

  • Maa, Formerly

  • Lenz Type Microphthalmia

  • Syndromic Microphthalmia 4

  • Microphthalmia Lenz Type

  • Microphthalmia Syndromic 1

  • Syndromic Microphthalmia Type 1

  • Microphthalmia Syndromic 4

  • Microphthalmia With Ankyloblepharon And Intellectual Disability

  • Microphthalmia, Lenz Type

  • Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

  • Microphthalmia, Syndromic, 1

  • Anop1

  • Microphthalmia, Syndromic, Type 1
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11824 CoA-C2-SGRGK-cCPP Inhibitor / Unkown
HY-RS08990 NAA40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20996 Naa40 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27513 Naa40 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NAA40 VGNC VGNC:54619
Macaca mulatta NAA40 VGNC VGNC:96719
Canis familiaris NAA40 VGNC VGNC:51882
Felis catus NAA40 VGNC VGNC:81977
Rattus norvegicus NAA40 RGD RGD:1565838
Mus musculus NAA40 MGD MGI:1918249
Others NAA40 NCBI