CoA-C2-SGRGK-cCPP
CoA-C2-SGRGK-cCPP is a NatD (NAA40) bisubstrate inhibitor with an IC50 of 78 nM and a Ki of 39 nM. CoA-C2-SGRGK-cCPP competitively targets the peptide substrate binding site and noncompetitively targets the CoA binding site of NatD to block acetyltransferase activity. CoA-C2-SGRGK-cCPP reduces cellular Nα-acetylation on histone H4, modulates EMT marker expression. CoA-C2-SGRGK-cCPP can be used for the research of non-small cell lung cancer.
For research use only. We do not sell to patients.
- Formula: C105H164N39O33P3S2
- Molecular Weight:2657.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NatD 78 nM (IC50) |
CoA-C2-SGRGK-cCPP (0.15 nM-30 μM; 30 min) potently inhibits purified NatD enzyme with a Ki of 39 nM and an IC50 of 78 nM, while its PEG-linked variant has reduced potency with a Ki of 65 nM and an IC50 of 130 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 2657.72
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Formula C105H164N39O33P3S2
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Sequence
{CoA-C2}-Ser-Gly-Arg-Gly-Lys-Lys-Cyclo(Gln-d{Arg}-Arg-d{Arg}-Arg-{Bta}-d{Phe}-Phe)
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Sequence Shortening
{CoA-C2}-SGRGKK-Cyclo(Q-d{Arg}-R-d{Arg}-R-{Bta}-d{Phe}-F)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CoA-C2-SGRGK-cCPP Related Classifications
HY-P11824 Related Classifications
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