CoA-C2-SGRGK-cCPP 

CoA-C2-SGRGK-cCPP is a NatD (NAA40) bisubstrate inhibitor with an IC₅₀ of 78 nM and a K_i of 39 nM. CoA-C2-SGRGK-cCPP competitively targets the peptide substrate binding site and noncompetitively targets the CoA binding site of NatD to block acetyltransferase activity. CoA-C2-SGRGK-cCPP reduces cellular Nα-acetylation on histone H4, modulates EMT marker expression. CoA-C2-SGRGK-cCPP can be used for the research of non-small cell lung cancer^[1].

CoA-C2-SGRGK-cCPP (0.15 nM-30 μM; 30 min) potently inhibits purified NatD enzyme with a K_i of 39 nM and an IC₅₀ of 78 nM, while its PEG-linked variant has reduced potency with a K_i of 65 nM and an IC₅₀ of 130 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2657.72

C₁₀₅H₁₆₄N₃₉O₃₃P₃S₂

{CoA-C2}-Ser-Gly-Arg-Gly-Lys-Lys-Cyclo(Gln-d{Arg}-Arg-d{Arg}-Arg-{Bta}-d{Phe}-Phe)

{CoA-C2}-SGRGKK-Cyclo(Q-d{Arg}-R-d{Arg}-R-{Bta}-d{Phe}-F)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ho YH, et al. A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity. ACS chemical biology. 2025 Oct 17;20(10):2512-2520.