SPHKAP - SPHK1 interactor, AKAP domain containing Gene

Also Known as SKIP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80309

About SPHKAP

Cytogenetic location: 2q36.3 Genomic coordinates (GRCh38): 2:227,979,955-228,181,687 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 3 paralogues. Biased expression in heart (RPKM 11.8), brain (RPKM 8.0) and 1 other tissue.

Summary

Enables protein kinase A binding activity. Predicted to be located in Z disc. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SPHKAP Products (2)

mRNA Protein Name
NM_001142644.2 NP_001136116.1 A-kinase anchor protein SPHKAP isoform 1
NM_030623.4 NP_085126.2 A-kinase anchor protein SPHKAP isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12080051 GOA
enables protein kinase A binding IDA
IDA: Inferred from direct assay
20394097 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPHKAP Protein Structure

AKAP_110

AKAP_110: A-kinase anchor protein 110 kDa (AKAP 110) (1594 - 1697)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1700 a.a.
Protein Preferred Names Protein Names

A-kinase anchor protein SPHKAP

  • SPHK1 (sphingosine kinase type 1) interacting protein

SPHKAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPHKAP Q2M3C7 SPHK1 Homo sapiens Q9NYA1
Confocal
12080051
Intra
SPHKAP Q2M3C7 SPHK1 Homo sapiens Q9NYA1
Anti Tag CoIP
12080051
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cns Neuroblastoma With Foxr2 Activation

  • Central Nervous System Neuroblastoma With Foxr2 Activation

  • Cns Nb-Foxr2

  • Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Neuroblastoma
Central Nervous System Germ Cell Tumor

  • Central Nervous System Germ Cell Tumour

  • Germ Cell Tumor Of The Cns

  • Germ Cell Tumour Of The Cns
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13670 SPHKAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SPHKAP VGNC VGNC:35212
Canis familiaris SPHKAP VGNC VGNC:46738
Felis catus SPHKAP VGNC VGNC:65636
Rattus norvegicus SPHKAP RGD RGD:1311951
Macaca mulatta SPHKAP VGNC VGNC:78022
Mus musculus SPHKAP MGD MGI:1924879