PDGFD - platelet derived growth factor D Gene

Homo sapiens

Also known as IEGF; SCDGFB; MSTP036; SCDGF-B

Gene ID: 80310 | Gene type: protein coding

About PDGFD

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:103,907,189-104,164,147 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues and 35 paralogues. Biased expression in adrenal (RPKM 66.8), ovary (RPKM 41.5) and 13 other tissues.

Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

PDGFD Products(2)

mRNA	Protein	Name
NM_025208.5	NP_079484.1	platelet-derived growth factor D isoform 1 precursor
NM_033135.4	NP_149126.1	platelet-derived growth factor D isoform 2 precursor

PDGFD Protein Structure

CUB

PDGF

0
100
200
300
370 a.a.

Protein Preferred Names

Protein Names

platelet-derived growth factor D

PDGF-D

Recombinant PDGFD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7280	PDGF-DD Protein, Human (CHO)	Q9GZP0 (S250-R370)	≥95%
HY-P701031	PDGF-DD Protein, Cynomolgus (HEK293, His)	Q9GZP0-1 (R19-R370)	≥95%

Related Diseases

Diseases

Alias

Proliferative Glomerulonephritis

Obstructive Nephropathy

Con	Congenital Obstructive Nephropathy
Nephropathy Obstructive

Familiar Ovarian Carcinoma

Mesangial Proliferative Glomerulonephritis

Glomerulonephritis - Mesangial Proliferative	Mesangial Proliferative Gn
Mesangioproliferative Glomerulonephritis	Glomerulonephritis Mesangial Proliferative

Bronchiectasis 2

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10253	PDGFD Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PDGFD	VGNC	VGNC:44371
Mus musculus	PDGFD	MGD	MGI:1919035
Felis catus	PDGFD	VGNC	VGNC:64082
Rattus norvegicus	PDGFD	RGD	RGD:621880
Macaca mulatta	PDGFD	VGNC	VGNC:75900
Bos taurus	PDGFD	VGNC	VGNC:32691
Others	PDGFD	NCBI

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