Abo - ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) Gene

Also Known as NAGAT

Species: Mus musculus

Gene Type: protein coding
Gene ID: 80908

Summary

Enables fucosylgalactoside 3-alpha-galactosyltransferase activity and glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Predicted to be involved in lipid glycosylation. Predicted to be located in cytoplasmic vesicle. Predicted to be active in Golgi apparatus and vesicle. Is expressed in alimentary system; male reproductive gland or organ; and spleen. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; gallbladder carcinoma; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Abo Products (2)

mRNA Protein Name
NM_001290444.2 NP_001277373.1 histo-blood group ABO system transferase isoform b
NM_030718.6 NP_109643.3 histo-blood group ABO system transferase isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables fucosylgalactoside 3-alpha-galactosyltransferase activity IDA
IDA: Inferred from direct assay
11278752 MGI
enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity IDA
IDA: Inferred from direct assay
11278752 MGI
Biological Process GO Annotation Evidence References Source
involved in oligosaccharide biosynthetic process IDA
IDA: Inferred from direct assay
11278752 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histo-blood group ABO system transferase

  • cis-AB transferase

  • fucosylglycoprotein 3-alpha-galactosyltransferase

  • fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase

  • glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase

  • glycoprotein-fucosylgalactoside alpha-galactosyltr

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991921 TNX-1500 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115635 ABO hydrochloride Modulator 98.70% Unkown
HY-E70051 alpha-1,3-N-Acetylgalactosaminyltransferase (Pm1138) / Unkown
HY-RS00109 ABO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17181 Abo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23632 Abo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W145682 Blood group H disaccharide / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abo NCBI NCBI:28