2. Gene
  3. GPR68 - G protein-coupled receptor 68 Gene

GPR68 - G protein-coupled receptor 68 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OGR1; AI2A6; GPR12A

Gene ID: 8111 | Gene type: protein coding

About GPR68

Cytogenetic location: 14q32.11 Genomic coordinates (GRCh38): 14:91,232,532-91,270,790 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in appendix (RPKM 1.7), skin (RPKM 1.5) and 22 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017]

GPR68 Products(12)

mRNA Protein Name
NM_001177676.2 NP_001171147.1 ovarian cancer G-protein coupled receptor 1
XM_005268110.5 XP_005268167.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_005268111.4 XP_005268168.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_047431791.1 XP_047287747.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_047431792.1 XP_047287748.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_047431790.1 XP_047287746.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_011537197.4 XP_011535499.1 ovarian cancer G-protein coupled receptor 1 isoform X1
NM_003485.3 NP_003476.3 ovarian cancer G-protein coupled receptor 1
XM_005268112.4 XP_005268169.1 ovarian cancer G-protein coupled receptor 1 isoform X1
NM_001348437.1 NP_001335366.1 ovarian cancer G-protein coupled receptor 1
XM_011537198.3 XP_011535500.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_011537199.3 XP_011535501.1 ovarian cancer G-protein coupled receptor 1 isoform X1

GPR68 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (39 - 286)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

ovarian cancer G-protein coupled receptor 1

ovarian cancer G protein-coupled receptor, 1

sphingosylphosphorylcholine receptor

Related Diseases

Diseases Alias
Amelogenesis Imperfecta, Hypomaturation Type, Iia6

AI2A6

Amelogenesis Imperfecta Type 2a6

Amelogenesis Imperfecta, Hypomaturation Type, 2a6
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Amelogenesis Imperfecta Hypomaturation Type

Aih

Hypomaturation Amelogenesis Imperfecta

Amelogenesis Imperfecta Type 2
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110279 Ogerin Modulator 99.58% Unkown
HY-154954 Ogremorphin Inhibitor 99.65% Unkown
HY-134494 MS48107 99.85% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPR68 VGNC VGNC:41443
Rattus norvegicus GPR68 RGD RGD:1309559
Macaca mulatta GPR68 VGNC VGNC:73141
Bos taurus GPR68 VGNC VGNC:29597
Mus musculus GPR68 MGD MGI:2441763