GPR68 - G protein-coupled receptor 68 Gene

Also Known as OGR1; AI2A6; GPR12A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8111

About GPR68

Cytogenetic location: 14q32.11 Genomic coordinates (GRCh38): 14:91,232,532-91,270,790 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in appendix (RPKM 1.7), skin (RPKM 1.5) and 22 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017]

GPR68 Products (12)

mRNA Protein Name
NM_001177676.2 NP_001171147.1 ovarian cancer G-protein coupled receptor 1
XM_005268110.5 XP_005268167.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_005268111.4 XP_005268168.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_047431791.1 XP_047287747.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_047431792.1 XP_047287748.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_047431790.1 XP_047287746.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_011537197.4 XP_011535499.1 ovarian cancer G-protein coupled receptor 1 isoform X1
NM_003485.3 NP_003476.3 ovarian cancer G-protein coupled receptor 1
XM_005268112.4 XP_005268169.1 ovarian cancer G-protein coupled receptor 1 isoform X1
NM_001348437.1 NP_001335366.1 ovarian cancer G-protein coupled receptor 1
XM_011537198.3 XP_011535500.1 ovarian cancer G-protein coupled receptor 1 isoform X1
XM_011537199.3 XP_011535501.1 ovarian cancer G-protein coupled receptor 1 isoform X1

GPR68 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (39 - 286)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

ovarian cancer G-protein coupled receptor 1

  • ovarian cancer G protein-coupled receptor, 1

  • sphingosylphosphorylcholine receptor

Related Diseases

Diseases Alias
Amelogenesis Imperfecta, Hypomaturation Type, Iia6

  • AI2A6

  • Amelogenesis Imperfecta Type 2a6

  • Amelogenesis Imperfecta, Hypomaturation Type, 2a6
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Amelogenesis Imperfecta Hypomaturation Type

  • Aih

  • Hypomaturation Amelogenesis Imperfecta

  • Amelogenesis Imperfecta Type 2
Amelogenesis Imperfecta

  • Ai

  • Congenital Enamel Hypoplasia

  • Al - [Amelogenesis Imperfecta]
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Cancer Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-154954 Ogremorphin Inhibitor 99.60% Unkown
HY-110279 Ogerin Modulator 99.94% Unkown
HY-134494 MS48107 99.90% Unkown
HY-105791S Sulazepam-d5 Activator / Unkown
HY-169704 Ogerin analogue 1 Control / Unkown
HY-181485 GPR68 antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPR68 VGNC VGNC:41443
Rattus norvegicus GPR68 RGD RGD:1309559
Macaca mulatta GPR68 VGNC VGNC:73141
Bos taurus GPR68 VGNC VGNC:29597
Mus musculus GPR68 MGD MGI:2441763
Others GPR68 NCBI