Dpyd - dihydropyrimidine dehydrogenase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81656

Summary

Enables several functions, including nucleotide binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Involved in several processes, including pyrimidine nucleobase metabolic process; response to glucocorticoid; and response to nutrient. Located in cytosol. Used to study colorectal Cancer. Biomarker of liver disease. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic Cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Dpyd Products (1)

mRNA Protein Name
NM_031027.2 NP_112289.2 dihydropyrimidine dehydrogenase [NADP(+)]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables FAD binding IDA
IDA: Inferred from direct assay
7451435 RGD
enables NADP binding IDA
IDA: Inferred from direct assay
7626590 RGD
enables dihydropyrimidine dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
1544906 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
7451435 RGD
enables iron ion binding IDA
IDA: Inferred from direct assay
7451435 RGD
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
8373446 RGD
enables uracil binding IDA
IDA: Inferred from direct assay
7626590 RGD
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IDA
IDA: Inferred from direct assay
3202908 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
19628084 RGD
involved in pyrimidine nucleobase catabolic process IDA
IDA: Inferred from direct assay
1629785 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
9819714 RGD
involved in response to nutrient IDA
IDA: Inferred from direct assay
8252488 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
9893640 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
8161345 RGD
involved in uracil metabolic process IDA
IDA: Inferred from direct assay
7626590 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
9348115 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydropyrimidine dehydrogenase [NADP(+)]

  • DHPDHase

  • DPD

  • dihydrothymine dehydrogenase

  • dihydrouracil dehydrogenase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17469 Gimeracil Inhibitor 99.81% Unkown

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03979 DPYD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W777340 Gimeracil-13C3 / Unkown
HY-17469S Gimeracil-13C3,15N / Unkown
HY-RS21328 Dpyd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27847 Dpyd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dpyd NCBI NCBI:1806