LSS - Lss lanosterol synthase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81681

Summary

Enables lanosterol synthase activity. Involved in Cholesterol biosynthetic process. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 4; cataract; cataract 44; and hypotrichosis 14. Orthologous to human LSS (lanosterol synthase). [provided by Alliance of Genome Resources, Apr 2022]

LSS Products (1)

mRNA Protein Name
NM_031049.2 NP_112311.2 lanosterol synthase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables lanosterol synthase activity IDA
IDA: Inferred from direct assay
1429550 RGD
enables lanosterol synthase activity IMP
IMP: Inferred from mutant phenotype
7568116 RGD
Biological Process GO Annotation Evidence References Source
involved in cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
1429550 RGD
involved in cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
16440058 RGD
involved in sterol metabolic process IMP
IMP: Inferred from mutant phenotype
16440058 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lanosterol synthase

  • 2,3-epoxysqualene--lanosterol cyclase

  • 2,3-oxidosqualene: lanosterol cyclase

  • OSC

  • lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)

  • oxidosqualene--lanosterol cyclase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160972 MM0299 Modulator 98.51% Unkown
HY-183143 Lss-11 / Unkown
HY-RS07706 LMBR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07866 LSS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174677 Human GATA1 mRNA / Unkown
HY-RS17396 Lss Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23851 Lss Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens LSS NCBI NCBI:4047