Sf3b1 - splicing factor 3b, subunit 1 Gene

Also Known as TA-8; Prp10; Targ4; 155kDa; SAP155; SF3b155; 2810001M05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 81898

Summary

Enables chromatin binding activity. Acts upstream of or within anterior/posterior pattern specification; blastocyst formation; and mRNA splicing, via spliceosome. Located in chromatin and nuclear matrix. Part of U2 snRNP. Is expressed in several structures, including central nervous system; endocrine gland; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and myelodysplastic syndrome. Orthologous to human SF3B1 (splicing factor 3b subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Sf3b1 Products (1)

mRNA Protein Name
NM_031179.2 NP_112456.2 splicing factor 3B subunit 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
15741318 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15741318 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
15741318 MGI
acts upstream of or within blastocyst formation IMP
IMP: Inferred from mutant phenotype
23211737 MGI
acts upstream of or within mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
23211737 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
20153721 MGI
located in nuclear matrix IDA
IDA: Inferred from direct assay
20153721 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20153721 MGI
part of small nuclear ribonucleoprotein complex IDA
IDA: Inferred from direct assay
20153721 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

splicing factor 3B subunit 1

  • SAP 155

  • pre-mRNA-splicing factor SF3b 155 kDa subunit

  • spliceosome-associated protein 155

  • splicing factor 3b, subunit 1, 155 kDa

  • transforming growth factor alpha regulated gene 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-111517 H3B-8800 Inhibitor 98.85% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16399 Pladienolide B Inhibitor 99.20% Unkown
HY-16466 Spliceostatin A 96.64% Unkown
HY-141881 PROTAC-O4I2 Degrader 99.56% Unkown
HY-168534 WX-02-23 Modulator 99.88% Unkown
HY-18772 O4I2 Ligand 99.18% Unkown
HY-181421 WX-02-43 Ligand 99.49% Unkown
HY-15867 Meayamycin B Inhibitor / Unkown
HY-122637 Sudemycin K Inhibitor / Unkown
HY-133924 18-Deoxyherboxidiene Inhibitor / Unkown
HY-120907 Sudemycin E Ligand / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sf3b1 NCBI NCBI:23451