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Abcb11 - ATP binding cassette subfamily B member 11 Gene

Also Known as Bsep; Spgp

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 83569

Summary

Enables ABC-type xenobiotic transporter activity; bile acid transmembrane transporter activity; and carbohydrate transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; response to 17alpha-ethynylestradiol; and xenobiotic transmembrane transport. Located in Golgi membrane; intracellular canaliculus; and recycling endosome membrane. Used to study cholestasis. Biomarker of alcoholic hepatitis and cholestasis. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11). [provided by Alliance of Genome Resources, Apr 2022]

Abcb11 Products (1)

mRNA	Protein	Name
NM_031760.1	NP_113948.1	bile salt export pump

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ABC-type bile acid transporter activity	IDA IDA: Inferred from direct assay	18985798	RGD
enables ABC-type bile acid transporter activity	IMP IMP: Inferred from mutant phenotype	15901796	RGD
enables ABC-type xenobiotic transporter activity	IMP IMP: Inferred from mutant phenotype	18245269	RGD
enables bile acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	17082223	RGD
enables canalicular bile acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	9545351	RGD
enables carbohydrate transmembrane transporter activity	IDA IDA: Inferred from direct assay	15901796	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15159385	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in bile acid and bile salt transport	IDA IDA: Inferred from direct assay	18985798	RGD
involved in bile acid and bile salt transport	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in bile acid and bile salt transport	IMP IMP: Inferred from mutant phenotype	15901796	RGD
involved in bile acid metabolic process	IDA IDA: Inferred from direct assay	9545351	RGD
involved in canalicular bile acid transport	IDA IDA: Inferred from direct assay	9545351	RGD
involved in canalicular bile acid transport	IMP IMP: Inferred from mutant phenotype	20398791	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	27090119	RGD
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	18829893	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	12702498	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	16452108	RGD
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	15901796	RGD
involved in transmembrane transport	IDA IDA: Inferred from direct assay	15901796	RGD
involved in xenobiotic export from cell	IMP IMP: Inferred from mutant phenotype	18245269	RGD
involved in xenobiotic metabolic process	IMP IMP: Inferred from mutant phenotype	18245269	RGD
involved in xenobiotic transmembrane transport	IMP IMP: Inferred from mutant phenotype	15901796	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	10748167	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	9545351	RGD
NOT located in basolateral plasma membrane	IMP IMP: Inferred from mutant phenotype	15121884	RGD
located in endosome	IDA IDA: Inferred from direct assay	11113123	RGD
located in intracellular canaliculus	IDA IDA: Inferred from direct assay	11113123	RGD
located in intracellular canaliculus	IMP IMP: Inferred from mutant phenotype	15121884	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	22262466	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	24643070	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	11113123	RGD
located in recycling endosome membrane	IMP IMP: Inferred from mutant phenotype	15121884	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
bile salt export pump	ATP-binding cassette sub-family B member 11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 sister of P-glycoprotein

Abcb11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Abcb11	O70127	Hax1	Rattus norvegicus	Q7TSE9	Anti Bait CoIP	15159385

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00050	ABCB11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-D3304	Cholyl-L-lysine fluorescein disodium		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcb11	NCBI	NCBI:8647