H4C1 - H4 clustered histone 1 Gene

Also Known as H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4FA; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; HIST1H4A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8359

About H4C1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,021,649-26,022,050 (from NCBI)

This gene has 1 transcript (splice variant), 10 orthologues and 14 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H4C1 Products (1)

mRNA	Protein	Name
NM_003538.4	NP_003529.1	histone H4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9540062	GOA
enables structural constituent of chromatin	IDA IDA: Inferred from direct assay	14718166	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of megakaryocyte differentiation	IDA IDA: Inferred from direct assay	18474616	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	14718166	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CENP-A containing nucleosome	IPI IPI: Inferred from physical interaction	21743476	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	14718166	GOA
part of nucleosome	IPI IPI: Inferred from physical interaction	20498094	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14585971	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	14718166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H4C1 Protein Structure

Histone

0
103 a.a.

Protein Preferred Names	Protein Names
histone H4	H4 histone family, member A

Recombinant H4C1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72336	Histone H4 Protein, Human/Xenopus laevis	P62805 (S2-G103)	≥ 95%, as determined by reducing SDS-PAGE.

H4C1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86642	Histone H4 Antibody (YA6334)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Holt-Oram Syndrome	HOS Atriodigital Dysplasia Heart-Hand Syndrome Atrio-Digital Syndrome Cardiac-Limb Syndrome Heart-Hand Syndrome, Type 1 Ventriculo-Radial Syndrome Hos1 Heart Hand Syndrome Atrio Digital Syndrome Hos 1 Atriodigital Dysplasia Type 1 Heart-Hand Syndrome Type 1 Holt Oram Syndrome
Hyperoxaluria, Primary, Type I	Primary Hyperoxaluria Type 1 HP1 Glycolic Aciduria Alanine-Glyoxylate Aminotransferase Deficiency Hepatic Agt Deficiency Oxalosis I Primary Hyperoxaluria, Type I Serine:Pyruvate Aminotransferase Deficiency Hyperoxaluria, Primary, Type 1 Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency Serine Pyruvate Aminotransferase Deficiency Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Oxalosis 1 Hyperoxaluria Primary 1 Hyperoxaluria Primary Type I Ph1 Primary Hyperoxaluria Type I Oxalosis Type 1 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Basilicata-Akhtar Syndrome	Mrxs36 MRXSBA Mental Retardation, X-Linked, Syndromic, Basilicata-Akhtar Type Mental Retardation, X-Linked, Syndromic 36 X-Linked Syndromic Mental Retardation 36 X-Linked Syndromic Mental Retardation Basilicata-Akhtar Type
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Biotin Deficiency	Biotin Deficiency Disease B7 Deficiency Biotan Vitamin Deficiency
Chromosome 16p13.3 Deletion Syndrome, Proximal	Rubinstein-Taybi Syndrome Broad Thumb-Hallux Syndrome Chromosome 16p13.3 Deletion Syndrome Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion Rubinstein Syndrome Broad Thumbs-Halluces Syndrome Rsts Rubinstein-Taybi Deletion Syndrome Rsts Deletion Syndrome Proximal Chromosome 16p13.3 Deletion Syndrome 16p13.3 Deletion Syndrome Broad Thumbs And Great Toes, Characteristic Facies, And Intellectual Disability Rts
Nut Midline Carcinoma	Nuclear Protein In Testis Midline Carcinoma Nmc
Koolen-De Vries Syndrome	KDVS 17q21.31 Microdeletion Syndrome Microdeletion 17q21.31 Syndrome Chromosome 17q21.31 Deletion Syndrome Koolen De Vries Syndrome Kansl1-Related Intellectual Disability Syndrome Chromosome 17q21.31 Microdeletion Syndrome Monosomy 17q21.31 17q21.31 Deletion Syndrome Koolen Syndrome Del(17)(Q21.31)
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05974	H4C1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05975	H4C2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05976	H4C3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05977	H4C4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05978	H4C6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05979	H4C8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19607	H4c1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	H4C1	MGD	MGI:2448423
Rattus norvegicus	H4C1	RGD	RGD:1306905