RIOK1 - RIO kinase 1 Gene

Also Known as RIO1; AD034; RRP10; bA288G3.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83732

About RIOK1

Cytogenetic location: 6p24.3 Genomic coordinates (GRCh38): 6:7,389,808-7,418,037 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 12.9), bone marrow (RPKM 9.3) and 25 other tissues.

Summary

The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for the last steps in the maturation of 40S subunits. [provided by RefSeq, Jan 2017]

RIOK1 Products (2)

mRNA Protein Name
NM_001348194.2 NP_001335123.1 serine/threonine-protein kinase RIO1 isoform 3
NM_031480.3 NP_113668.2 serine/threonine-protein kinase RIO1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
21081503 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in maturation of SSU-rRNA IMP
IMP: Inferred from mutant phenotype
22072790 GOA
involved in positive regulation of rRNA processing IMP
IMP: Inferred from mutant phenotype
22072790 GOA
involved in ribosomal small subunit biogenesis IMP
IMP: Inferred from mutant phenotype
22072790 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in cytosol IDA
IDA: Inferred from direct assay
21081503 GOA
part of methyltransferase complex IMP
IMP: Inferred from mutant phenotype
21081503 GOA
part of preribosome, small subunit precursor IDA
IDA: Inferred from direct assay
22072790 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIOK1 Protein Structure

RIO1

RIO1: RIO1 family (193 - 380)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 568 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase RIO1

RIOK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
RIOK1 Q9BRS2 PRMT5 Homo sapiens O14744
Anti Tag CoIP
35271311
Intra
RIOK1 Q9BRS2 PRMT5 Homo sapiens O14744
Pull Down
32707033
Intra
RIOK1 Q9BRS2 PRMT5 Homo sapiens O14744
Anti Tag CoIP
25852190
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RIOK1 Proteins

Referencia número Nombre del producto Accession Pureza
HY-P76578 RIOK1 Protein, Human (sf9, His-GST) Q9BRS2 (M1-K568) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cecum Carcinoma

  • Cecum Cancer

  • Caecum Carcinoma

  • Carcinoma Of Cecum

  • Cecal Cancer

  • Malignant Neoplasm Of Caecum

  • Malignant Tumor Of The Cecum
Cecum Adenocarcinoma

  • Cecal Adenocarcinoma

  • Adenocarcinoma Of Cecum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-116559 TIBI Inhibitor 99.62% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RIOK1 RGD RGD:1306086
Macaca mulatta RIOK1 VGNC VGNC:76767
Mus musculus RIOK1 MGD MGI:1918590
Canis familiaris RIOK1 VGNC VGNC:54987
Bos taurus RIOK1 VGNC VGNC:50051
Felis catus RIOK1 VGNC VGNC:102503
Others RIOK1 NCBI