Wasf1 - WASP family, member 1 Gene

Also Known as Scar; WAVE; WAVE-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 83767

Summary

Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to contribute to small GTPase binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; and modification of postsynaptic actin Cytoskeleton. Acts upstream of or within lamellipodium morphogenesis. Located in lamellipodium; mitochondrial outer membrane; and postsynapse. Is expressed in several structures, including central nervous system; liver; spleen; testis; and tooth. Orthologous to human WASF1 (WASP family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Wasf1 Products (3)

mRNA Protein Name
NM_001379453.1 NP_001366382.1 actin-binding protein WASF1 isoform 1
NM_001379454.1 NP_001366383.1 actin-binding protein WASF1 isoform 2
NM_031877.3 NP_114083.1 actin-binding protein WASF1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12931191 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to brain-derived neurotrophic factor stimulus IMP
IMP: Inferred from mutant phenotype
27605705 MGI
involved in dendrite extension IMP
IMP: Inferred from mutant phenotype
27605705 MGI
acts upstream of or within lamellipodium morphogenesis IMP
IMP: Inferred from mutant phenotype
17664349 MGI
involved in modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
16862120 MGI
involved in modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
16862120 MGI
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
27605705 MGI
involved in positive regulation of neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27605705 MGI
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
27605705 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17664349 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
15148305 MGI
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
12931191 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
12931191 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
16190876 MGI
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
16190876 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin-binding protein WASF1

wiskott-Aldrich syndrome protein family member 1

  • WAS protein family, member 1

  • WASP family 1

  • WASP family protein member 1

  • protein WAVE-1

Wasf1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Wasf1 Q8R5H6 Pik3r1 Mus musculus P26450
Anti Bait CoIP
21946561
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15742 WASF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22917 Wasf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29431 Wasf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wasf1 NCBI NCBI:8936