MIXL1 - Mix paired-like homeobox Gene

Also Known as MIX; MIXL; MILD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83881

About MIXL1

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:226,223,664-226,227,060 (from NCBI)

This gene has 3 transcripts (splice variants), 153 orthologues and 50 paralogues. Biased expression in lymph node (RPKM 1.1), urinary bladder (RPKM 0.8) and 11 other tissues.

Summary

Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008]

MIXL1 Products (2)

mRNA Protein Name
NM_001282402.2 NP_001269331.1 homeobox protein MIXL1 isoform 1
NM_031944.3 NP_114150.1 homeobox protein MIXL1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
22164283 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIXL1 Protein Structure

Homeobox

Homeobox: Homeobox domain (87 - 143)

  • 0
  • 100
  • 200
  • 232 a.a.
Protein Preferred Names Protein Names

homeobox protein MIXL1

  • MIX1 homeobox-like protein 1

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group F

  • Fanconi Anemia Complementation Group F

  • FANCF
Germ Cell And Embryonal Cancer

  • Germ Cell And Embryonal Neoplasm
Germ Cell Cancer

  • Malignant Germ Cell Tumor

  • Neoplasms, Germ Cell And Embryonal

  • Germ Cell Neoplasm

  • Germ Cell Tumour

  • Malignant Tumor Of The Germ Cell

  • Neoplasms Germ Cell

  • Malignant Germ Cell Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08469 MIXL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22640 Mixl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29155 Mixl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MIXL1 VGNC VGNC:74730
Bos taurus MIXL1 VGNC VGNC:31488
Rattus norvegicus MIXL1 RGD RGD:1310011
Mus musculus MIXL1 MGD MGI:1351322