Tbx19 - T-box 19 Gene

Also Known as Tpit; D1Ertd754e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 83993

Summary

This gene encodes a member of a family of transcription factors containing a characteristic T-box DNA-binding domain. The encoded protein promotes expression of the pro-opiomelanocortin (POMC) gene, which is important for the differentiation of cells in the pituitary gland. [provided by RefSeq, Mar 2013]

Tbx19 Products (1)

mRNA	Protein	Name
NM_032005.4	NP_114394.1	T-box transcription factor TBX19

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12651892	MGI
enables DNA binding	IMP IMP: Inferred from mutant phenotype	11447259	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11290323	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	11290323	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11447259	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	11290323	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23070814	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12651892	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	12651892	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	11447259	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11447259	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11290323	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	11447259	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12651892	MGI
acts upstream of or within regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	23070814	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11447259	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
T-box transcription factor TBX19	T-box factor, pituitary T-box protein 19

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14274	TBX19 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21780	Tbx19 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28297	Tbx19 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbx19	NCBI	NCBI:9095