B3GNT5 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 Gene

Also Known as B3GN-T5; beta3Gn-T5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84002

About B3GNT5

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:183,253,253-183,273,385 (from NCBI)

This gene has 12 transcripts (splice variants), 250 orthologues and 15 paralogues. Broad expression in bone marrow (RPKM 17.8), small intestine (RPKM 13.8) and 20 other tissues.

Summary

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. [provided by RefSeq, Jul 2008]

B3GNT5 Products (1)

mRNA Protein Name
NM_032047.5 NP_114436.1 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity IDA
IDA: Inferred from direct assay
11384981 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in central nervous system development IDA
IDA: Inferred from direct assay
11384981 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

B3GNT5 Protein Structure

Galactosyl_T

Galactosyl_T: Galactosyltransferase (102 - 299)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
Protein Preferred Names Protein Names

lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

  • BGnT-5

B3GNT5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
B3GNT5 Q9BYG0 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
B3GNT5 Q9BYG0 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
B3GNT5 Q9BYG0 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Salt And Pepper Syndrome

  • Salt & Pepper Syndrome

  • Salt-And-Pepper Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01312 B3GNT5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21099 B3gnt5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27617 B3gnt5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus B3GNT5 VGNC VGNC:60057
Macaca mulatta B3GNT5 VGNC VGNC:70077
Canis familiaris B3GNT5 VGNC VGNC:38343
Rattus norvegicus B3GNT5 RGD RGD:70955
Mus musculus B3GNT5 MGD MGI:2137302
Bos taurus B3GNT5 VGNC VGNC:26381
Others B3GNT5 NCBI