Ralbp1 - ralA binding protein 1 Gene

Also Known as RIP1; RLIP76

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84014

Summary

Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including mitotic spindle organization; negative regulation of smooth muscle cell proliferation; and regulation of intracellular signal transduction. Located in neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ralbp1 Products (2)

mRNA Protein Name
NM_001393664.1 NP_001380593.1 ralA-binding protein 1
NM_032067.2 NP_114456.2 ralA-binding protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
7623849 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21242975 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
7623849 RGD
Biological Process GO Annotation Evidence References Source
involved in endocytosis IMP
IMP: Inferred from mutant phenotype
19823667 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
16648138 RGD
involved in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
23788031 RGD
involved in regulation of Cdc42 protein signal transduction IDA
IDA: Inferred from direct assay
7623849 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels EXP
EXP: Inferred from Experiment
19823667 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: Inferred from direct assay
19823667 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: Inferred from mutant phenotype
19823667 RGD
involved in small GTPase-mediated signal transduction IPI
IPI: Inferred from physical interaction
7623849 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
19823667 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
19823667 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
19823667 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ralA-binding protein 1

  • DNP-SG ATPase

  • cytocentrin

  • dinitrophenyl S-glutathione ATPase

  • ral-interacting protein 1

Ralbp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Ralbp1 Q62796 CCND1 Homo sapiens P24385
Pull Down
21242975
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125987 RBC6 Inhibitor 98.88% Unkown
HY-123464 RBC10 Inhibitor 98.0% Unkown
HY-RS11629 RALBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11845 REPS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18714 Ralbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25201 Ralbp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ralbp1 NCBI NCBI:10928