NAE1 - Nae1 NEDD8 activating enzyme E1 subunit 1 Gene

Also Known as Appbp1; RGD1563180

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84019

Summary

Predicted to enable NEDD8 activating enzyme activity; protein heterodimerization activity; and ubiquitin protein Ligase binding activity. Predicted to be involved in several processes, including mitotic DNA replication checkpoint signaling; neuron apoptotic process; and protein neddylation. Located in early endosome and membrane raft. Biomarker of middle cerebral artery infarction. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

NAE1 Products (1)

mRNA Protein Name
NM_032072.4 NP_114461.3 NEDD8-activating enzyme E1 regulatory subunit

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
17611268 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NEDD8-activating enzyme E1 regulatory subunit

  • APP-binding protein 1

  • amyloid beta precursor protein-binding protein 1, 59 kDa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133558 VII-31 99.63% Unkown
HY-161268 NAE-IN-1 99.75% Unkown
HY-RS09007 NAE1 Human Pre-designed siRNA Set A / Unkown
HY-RS17023 Nae1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23466 Nae1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NAE1 NCBI NCBI:8883