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Ptger4 - prostaglandin E receptor 4 Gene

Also Known as EP4; Ptger; Ptgerep4

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 84023

Summary

Enables prostaglandin E receptor activity. Involved in several processes, including regulation of circadian sleep/wake cycle, sleep; regulation of cytokine production; and regulation of secretion. Located in several cellular components, including neuron projection terminus; neuronal cell body; and nuclear membrane. Used to study acute kidney failure; cystitis; end stage renal disease; myocarditis; and osteoporosis. Biomarker of retinal ischemia and transient cerebral ischemia. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Ptger4 Products (1)

mRNA	Protein	Name
NM_032076.3	NP_114465.3	prostaglandin E2 receptor EP4 subtype

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables prostaglandin E receptor activity	IDA IDA: Inferred from direct assay	10336471	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19233324	RGD
involved in JNK cascade	IDA IDA: Inferred from direct assay	19233324	RGD
involved in bone development	IDA IDA: Inferred from direct assay	19233324	RGD
involved in cAMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	11278900	RGD
involved in cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	11278900	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	12888618	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	11207665	RGD
involved in cellular response to prostaglandin E stimulus	IEP IEP: Inferred from expression pattern	11248657	RGD
involved in cellular response to prostaglandin E stimulus	IMP IMP: Inferred from mutant phenotype	11278900	RGD
involved in chemokinesis	IMP IMP: Inferred from mutant phenotype	8679543	RGD
involved in ductus arteriosus closure	IMP IMP: Inferred from mutant phenotype	16303610	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	10819751	RGD
involved in maternal process involved in parturition	IEP IEP: Inferred from expression pattern	19801535	RGD
involved in negative regulation of ductus arteriosus closure	IMP IMP: Inferred from mutant phenotype	16303610	RGD
involved in negative regulation of endothelin production	IMP IMP: Inferred from mutant phenotype	15560120	RGD
involved in negative regulation of hydrogen peroxide metabolic process	IMP IMP: Inferred from mutant phenotype	11991626	RGD
involved in negative regulation of interleukin-1 alpha production	IMP IMP: Inferred from mutant phenotype	15560120	RGD
involved in negative regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	11991626	RGD
involved in negative regulation of peptide secretion	IMP IMP: Inferred from mutant phenotype	15560120	RGD
involved in negative regulation of small intestine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	11991626	RGD
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	15560120	RGD
involved in positive regulation of antral ovarian follicle growth	IMP IMP: Inferred from mutant phenotype	15944932	RGD
involved in positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	11792579	RGD
involved in positive regulation of calcitonin secretion	IMP IMP: Inferred from mutant phenotype	11278900	RGD
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	14751573	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19233324	RGD
involved in positive regulation of chemokinesis	IMP IMP: Inferred from mutant phenotype	8679543	RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: Inferred from mutant phenotype	10923657	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17673547	RGD
involved in positive regulation of hyaluronan biosynthetic process	IMP IMP: Inferred from mutant phenotype	17080198	RGD
involved in positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	15560120	RGD
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	15944932	RGD
involved in positive regulation of matrix metallopeptidase secretion	IMP IMP: Inferred from mutant phenotype	8679543	RGD
involved in positive regulation of mucus secretion	IMP IMP: Inferred from mutant phenotype	11991626	RGD
involved in positive regulation of neutrophil extravasation	IMP IMP: Inferred from mutant phenotype	15944932	RGD
involved in positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	14751573	RGD
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	14751573	RGD
involved in positive regulation of ovarian follicle development	IMP IMP: Inferred from mutant phenotype	15944932	RGD
involved in positive regulation of protein modification process	IMP IMP: Inferred from mutant phenotype	17067562	RGD
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	8679543	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	17080198	RGD
involved in positive regulation of substance P secretion	IMP IMP: Inferred from mutant phenotype	11278900	RGD
involved in positive regulation of substance P secretion, neurotransmission	IMP IMP: Inferred from mutant phenotype	15292051	RGD
involved in positive regulation of urine volume	IMP IMP: Inferred from mutant phenotype	18287210	RGD
involved in positive regulation of wound healing	IMP IMP: Inferred from mutant phenotype	16515909	RGD
involved in regulation of circadian sleep/wake cycle, wakefulness	IMP IMP: Inferred from mutant phenotype	10923657	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	10882227	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	10800959	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19801535	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	19801535	RGD
involved in response to prostaglandin E	IEP IEP: Inferred from expression pattern	10800959	RGD
involved in response to salt	IEP IEP: Inferred from expression pattern	10432392	RGD
involved in response to water-immersion restraint stress	IEP IEP: Inferred from expression pattern	10882227	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	10800959	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in neuron projection terminus	IDA IDA: Inferred from direct assay	15292051	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15292051	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	10336471	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
prostaglandin E2 receptor EP4 subtype	PGE receptor, EP4 subtype PGE2 receptor EP4 subtype prostaglandin E receptor 4 (subtype EP4) prostaglandin E2 receptor type 4 prostanoid EP4 receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11378	PTGER4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18874	Ptger4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25365	Ptger4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptger4	NCBI	NCBI:5734