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SPARCL1 - SPARC like 1 Gene

Also Known as SC1; MAST9; PIG33; MAST 9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8404

About SPARCL1

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:87,473,335-87,529,376 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues and 1 paralogue. Broad expression in brain (RPKM 777.2), endometrium (RPKM 500.6) and 20 other tissues.

Summary

Predicted to enable calcium ion binding activity; Collagen binding activity; and extracellular matrix binding activity. Predicted to be involved in anatomical structure development and regulation of synapse organization. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SPARCL1 Products (4)

mRNA	Protein	Name
NM_001128310.3	NP_001121782.1	SPARC-like protein 1 isoform 1 precursor
NM_001291976.2	NP_001278905.1	SPARC-like protein 1 isoform 2
NM_001291977.2	NP_001278906.1	SPARC-like protein 1 isoform 2
NM_004684.6	NP_004675.3	SPARC-like protein 1 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20926826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPARCL1 Protein Structure

FOLN

Kazal_1

SPARC_Ca_bdg

0
200
400
600
664 a.a.

Protein Preferred Names	Protein Names
SPARC-like protein 1	SPARC-like 1 (hevin)

SPARCL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SPARCL1	Q14515	MYOC	Homo sapiens	Q99972	ELISA	20926826
Intra	SPARCL1	Q14515	MYOC	Homo sapiens	Q99972	Y2H	20926826

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13632	SPARCL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18885	Sparcl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25376	Sparcl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SPARCL1	RGD	RGD:2531
Felis catus	SPARCL1	VGNC	VGNC:65602
Bos taurus	SPARCL1	VGNC	VGNC:35172
Macaca mulatta	SPARCL1	VGNC	VGNC:77855
Mus musculus	SPARCL1	MGD	MGI:108110
Others	SPARCL1	NCBI