PYM1 - PYM homolog 1, exon junction complex associated factor Gene

Homo sapiens

Also known as PYM; WIBG

Gene ID: 84305 | Gene type: protein coding

About PYM1

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,901,413-55,927,894 (from NCBI)

This gene has 7 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in esophagus (RPKM 16.0), colon (RPKM 12.9) and 25 other tissues.

Summary

Enables ribosome binding activity. Involved in exon-exon junction complex disassembly; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and positive regulation of translation. Located in cell junction; cytosol; and nuclear lumen. Part of exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

PYM1 Products(2)

mRNA	Protein	Name
NM_001143853.1	NP_001137325.1	partner of Y14 and mago isoform 2
NM_032345.3	NP_115721.1	partner of Y14 and mago isoform 1

PYM1 Protein Structure

Mago-bind

0
100
204 a.a.

Protein Preferred Names

Protein Names

partner of Y14 and mago

protein wibg homolog

Recombinant PYM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71433	WIBG Protein, Human (His)	Q9BRP8 (M1-L204)	≥95%

Related Diseases

Diseases

Alias

Palmoplantar Keratoderma, Punctate Type Ia

Keratosis Palmoplantaris Papulosa	Punctate Palmoplantar Keratoderma Type I
Ppkp1	Keratodermia Palmoplantaris Papulosa, Buschke-Fischer-Brauer Type
PPKP1A	Kppp1
Punctate Palmoplantar Keratoderma Type 1	Palmoplantar Keratoderma, Punctate Type 1a
Palmoplantar Keratoderma, Punctate Type I	Keratoderma, Palmoplantar, Punctate Type Ia
Punctate Palmoplantar Keratoderma Type 1a	Punctate Palmoplantar Keratoderma Type 1b
Brauer-Buschke-Fischer Syndrome	Keratoderma, Palmoplantar Punctate Type 1
Type I Punctate Palmoplantar Keratoderma	Buschke-Fischer-Brauer Syndrome
Keratoderma, Palmoplantar, Punctate 1a	Keratodermia Palmoplantaris Papulosa Buschke-Fischer-Brauer Type
Keratosis Punctate Palmoplantaris Buschke-Fisher-Brauer Type	Punctate Palmoplantar Keratoderma Type Ia
Keratoderma, Palmoplantar, Punctate Type 1	Keratoderma, Palmoplantar, Punctate, Type Ia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11494	PYM1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PYM1	VGNC	VGNC:76570
Felis catus	PYM1	VGNC	VGNC:64453
Canis familiaris	PYM1	VGNC	VGNC:45228
Bos taurus	PYM1	VGNC	VGNC:33592
Rattus norvegicus	PYM1	RGD	RGD:1306096
Mus musculus	PYM1	MGD	MGI:1925678