PYM1 - PYM homolog 1, exon junction complex associated factor Gene

Also Known as PYM; WIBG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84305

About PYM1

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,901,413-55,927,894 (from NCBI)

This gene has 7 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in esophagus (RPKM 16.0), colon (RPKM 12.9) and 25 other tissues.

Summary

Enables ribosome binding activity. Involved in exon-exon junction complex disassembly; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and positive regulation of translation. Located in cell junction; cytosol; and nuclear lumen. Part of exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

PYM1 Products (2)

mRNA Protein Name
NM_001143853.1 NP_001137325.1 partner of Y14 and mago isoform 2
NM_032345.3 NP_115721.1 partner of Y14 and mago isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16209946 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
18026120 GOA
Biological Process GO Annotation Evidence References Source
involved in exon-exon junction complex disassembly IDA
IDA: Inferred from direct assay
19410547 GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
IDA: Inferred from direct assay
19410547 GOA
involved in positive regulation of translation IDA
IDA: Inferred from direct assay
18026120 GOA
Cellular Component GO Annotation Evidence References Source
part of exon-exon junction complex IDA
IDA: Inferred from direct assay
18026120 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PYM1 Protein Structure

Mago-bind

Mago-bind: Mago binding (14 - 38)

  • 0
  • 100
  • 204 a.a.
Protein Preferred Names Protein Names

partner of Y14 and mago

  • protein wibg homolog

PYM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PYM1 Q9BRP8 MAGOH Homo sapiens P61326
Anti Tag CoIP
25616068
Intra
PYM1 Q9BRP8 MAGOH Homo sapiens P61326
Anti Tag CoIP
19478851
Intra
PYM1 Q9BRP8 MAGOH Homo sapiens P61326
Anti Bait CoIP
19410547
Intra
PYM1 Q9BRP8 MAGOH Homo sapiens P61326
Anti Bait CoIP
25616068
Cross
PYM1 Q9BRP8 mta_hhv8p Human herpesvirus 8 Q2HR75
Anti Bait CoIP
20436455
Cross
PYM1 Q9BRP8 mta_hhv8p Human herpesvirus 8 Q2HR75
Density Sedimentation
20436455
Intra
PYM1 Q9BRP8 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
Cross
PYM1 Q9BRP8 Q99IB8-PRO_0000045592 Hepatitis C virus Q99IB8-PRO_0000045592
Anti Bait CoIP
25616068
Cross
PYM1 Q9BRP8 Q99IB8-PRO_0000045592 Hepatitis C virus Q99IB8-PRO_0000045592
Anti Tag CoIP
25616068
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PYM1 Proteins

Cat. No. 상품명 Accession Purity
HY-P71433 WIBG Protein, Human (His) Q9BRP8 (M1-L204) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Palmoplantar Keratoderma, Punctate Type Ia

  • Keratosis Palmoplantaris Papulosa

  • Punctate Palmoplantar Keratoderma Type I

  • Ppkp1

  • Keratodermia Palmoplantaris Papulosa, Buschke-Fischer-Brauer Type

  • PPKP1A

  • Kppp1

  • Punctate Palmoplantar Keratoderma Type 1

  • Palmoplantar Keratoderma, Punctate Type 1a

  • Palmoplantar Keratoderma, Punctate Type I

  • Keratoderma, Palmoplantar, Punctate Type Ia

  • Punctate Palmoplantar Keratoderma Type 1a

  • Punctate Palmoplantar Keratoderma Type 1b

  • Brauer-Buschke-Fischer Syndrome

  • Keratoderma, Palmoplantar Punctate Type 1

  • Type I Punctate Palmoplantar Keratoderma

  • Buschke-Fischer-Brauer Syndrome

  • Keratoderma, Palmoplantar, Punctate 1a

  • Keratodermia Palmoplantaris Papulosa Buschke-Fischer-Brauer Type

  • Keratosis Punctate Palmoplantaris Buschke-Fisher-Brauer Type

  • Punctate Palmoplantar Keratoderma Type Ia

  • Keratoderma, Palmoplantar, Punctate Type 1

  • Keratoderma, Palmoplantar, Punctate, Type Ia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-W009641 1-Pyrenemethanol 99.69% Unkown
HY-RS11494 PYM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PYM1 VGNC VGNC:76570
Felis catus PYM1 VGNC VGNC:64453
Canis familiaris PYM1 VGNC VGNC:45228
Bos taurus PYM1 VGNC VGNC:33592
Rattus norvegicus PYM1 RGD RGD:1306096
Mus musculus PYM1 MGD MGI:1925678
Others PYM1 NCBI