Ctnnb1 - catenin beta 1 Gene

Also Known as Catnb

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84353

About Ctnnb1

Primary_assembly 8: 120,639,995-120,667,111 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 217 orthologues, 5 paralogues and is associated with 116 phenotypes. Biased expression in Kidney (RPKM 1354.8), Lung (RPKM 133.) and 9 other tissues.

Summary

Enables Cadherin binding activity; ionotropic glutamate receptor binding activity; and nitric-oxide synthase binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; cellular response to lithium ion; and cellular response to mechanical stimulus. Located in several cellular components, including dendritic shaft; intercalated disc; and nuclear membrane. Part of protein-containing complex. Colocalizes with neuron projection. Used to study colon adenocarcinoma and lung carcinoma. Biomarker of Alzheimer's disease and colorectal Cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ Cancer (multiple); and urinary system Cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Ctnnb1 Products (1)

mRNA Protein Name
NM_053357.2 NP_445809.2 catenin beta-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-catenin binding IPI
IPI: Inferred from physical interaction
12960056 RGD
enables cadherin binding IDA
IDA: Inferred from direct assay
9515794 RGD
enables cadherin binding IPI
IPI: Inferred from physical interaction
12533412 RGD
enables delta-catenin binding IPI
IPI: Inferred from physical interaction
12960056 RGD
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
20007479 RGD
enables nitric-oxide synthase binding IPI
IPI: Inferred from physical interaction
15858215 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8794867 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
8834786 RGD
Biological Process GO Annotation Evidence References Source
involved in Schwann cell proliferation IMP
IMP: Inferred from mutant phenotype
17941050 RGD
involved in bone remodeling IEP
IEP: Inferred from expression pattern
29224185 RGD
involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
12533412 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
12095987 RGD
involved in cellular response to insulin-like growth factor stimulus IEP
IEP: Inferred from expression pattern
20042609 RGD
involved in cellular response to insulin-like growth factor stimulus IMP
IMP: Inferred from mutant phenotype
20042609 RGD
involved in cellular response to lithium ion IEP
IEP: Inferred from expression pattern
12610652 RGD
involved in cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
20042609 RGD
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in epididymis development IEP
IEP: Inferred from expression pattern
12960056 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
17236583 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
17356920 RGD
involved in myoblast differentiation IEP
IEP: Inferred from expression pattern
17222478 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23270756 RGD
involved in odontogenesis of dentin-containing tooth IEP
IEP: Inferred from expression pattern
10681393 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
22252247 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
17136310 RGD
involved in response to cytokine IDA
IDA: Inferred from direct assay
17888912 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
22252247 RGD
involved in response to estrogen IDA
IDA: Inferred from direct assay
17170212 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
17708712 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18174280 RGD
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
8834786 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12960056 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
12610652 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
12123611 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
25586361 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
12960056 RGD
located in membrane IDA
IDA: Inferred from direct assay
16815997 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
12610652 RGD
located in nucleus IDA
IDA: Inferred from direct assay
16690606 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20042609 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
12610652 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12533412 RGD
located in tight junction IDA
IDA: Inferred from direct assay
12960056 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctnnb1 Protein Structure

CTNNAbd_CTNNB1

CTNNAbd_CTNNB1: cd21724 (77 - 150)

SRP1

SRP1: cl34886 (141 - 430)

ARM

ARM: sd00043 (152 - 177)

ARM

ARM: sd00043 (187 - 220)

ARM

ARM: smart00185 (229 - 261)

ARM

ARM: sd00043 (229 - 261)

ARM

ARM: sd00043 (269 - 305)

ARM

ARM: sd00043 (311 - 346)

ARM

ARM: smart00185 (349 - 389)

ARM

ARM: sd00043 (353 - 388)

ARM

ARM: sd00043 (401 - 426)

Arm

Arm: pfam00514 (430 - 472)

ARM

ARM: sd00043 (434 - 472)

ARM

ARM: sd00043 (481 - 516)

ARM

ARM: sd00043 (523 - 581)

Arm

Arm: pfam00514 (582 - 621)

ARM

ARM: sd00043 (586 - 620)

ARM

ARM: sd00043 (628 - 661)

  • 0
  • 200
  • 400
  • 600
  • 781 a.a.
Protein Preferred Names Protein Names

catenin beta-1

  • beta-catenin

  • catenin (cadherin associated protein), beta 1, 88kDa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161719 NF764 Degrader 99.19% Unkown
HY-120675 SSTC3 99.37% Unkown
HY-160765 WNTinib 99.95% Unkown
HY-RS03307 Ctnnb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03306 CTNNB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184469 DVL1/P-gp-IN-1 / Unkown
HY-RS03308 Ctnnb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctnnb1 NCBI NCBI:1499