Bnip3 - BCL2 interacting protein 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84480

Summary

Enables identical protein binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; central nervous system development; and positive regulation of cell death. Located in dendrite; mitochondrion; and nucleoplasm. Used to study congestive heart failure. Biomarker of several diseases, including cerebrovascular disease (multiple); chronic obstructive pulmonary disease; end stage renal disease; obesity; and retinal detachment. Orthologous to human BNIP3 (BCL2 interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Bnip3 Products (1)

mRNA Protein Name
NM_053420.3 NP_445872.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25436615 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
25436615 RGD
Biological Process GO Annotation Evidence References Source
involved in autophagic cell death IMP
IMP: Inferred from mutant phenotype
19539716 RGD
involved in cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
12226479 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
28661226 RGD
involved in cellular response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
19539716 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
17379825 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
16765336 RGD
involved in negative regulation of mitochondrial membrane permeability involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
17980495 RGD
involved in negative regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
17980495 RGD
involved in neuron apoptotic process IDA
IDA: Inferred from direct assay
14972662 RGD
involved in oligodendrocyte differentiation IEP
IEP: Inferred from expression pattern
12787069 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16645637 RGD
involved in positive regulation of autophagy of mitochondrion IMP
IMP: Inferred from mutant phenotype
23698117 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IDA
IDA: Inferred from direct assay
23028672 RGD
involved in positive regulation of mitochondrial calcium ion concentration IMP
IMP: Inferred from mutant phenotype
25489073 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
22639046 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
20157446 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
14972662 RGD
involved in response to oxygen-glucose deprivation IEP
IEP: Inferred from expression pattern
22639046 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14972662 RGD
located in dendrite IDA
IDA: Inferred from direct assay
14972662 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
14972662 RGD
located in nucleus IDA
IDA: Inferred from direct assay
14972662 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

  • BCL2/adenovirus E1B 19 kDa-interacting protein 3

  • BCL2/adenovirus E1B interacting protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-121859 RU28362 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bnip3 NCBI NCBI:664