Ncoa3 - nuclear receptor coactivator 3 Gene

Also Known as Aib1; Tram-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84584

Summary

Enables several functions, including nuclear receptor binding activity; nuclear receptor coactivator activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including male gonad development; positive regulation of intracellular Estrogen receptor signaling pathway; and regulation of transcription, DNA-templated. Located in Golgi apparatus; nucleus; and perinuclear region of cytoplasm. Used to study breast Cancer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NCOA3 (nuclear receptor coactivator 3). [provided by Alliance of Genome Resources, Apr 2022]

Ncoa3 Products (1)

mRNA Protein Name
NM_053454.1 NP_445906.1 nuclear receptor coactivator 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15166231 RGD
enables nuclear androgen receptor binding IPI
IPI: Inferred from physical interaction
17223690 RGD
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
11818503 RGD
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
11713241 RGD
enables peroxisome proliferator activated receptor binding IPI
IPI: Inferred from physical interaction
20132223 RGD
enables protein-containing complex binding IMP
IMP: Inferred from mutant phenotype
20132223 RGD
Biological Process GO Annotation Evidence References Source
involved in cerebellum development IEP
IEP: Inferred from expression pattern
10803578 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
16189181 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21454665 RGD
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11713241 RGD
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
21454665 RGD
involved in positive regulation of intracellular estrogen receptor signaling pathway IDA
IDA: Inferred from direct assay
11713241 RGD
involved in positive regulation of intracellular steroid hormone receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16179382 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17481888 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16179382 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor coactivator 3

  • AIB-1

  • NCoA-3

  • amplified in breast cancer-1 protein homolog

  • thyroid hormone receptor activator molecule 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173033 MI-883 99.57% Unkown
HY-RS09091 NCOA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P11829 ACTR-AD1 2L Inhibitor / Unkown
HY-RS20451 Ncoa3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26960 Ncoa3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncoa3 NCBI NCBI:8202