GPR174 - G protein-coupled receptor 174 Gene

Also Known as FKSG79; GPCR17; LYPSR3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84636

About GPR174

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:79,144,688-79,175,318 (from NCBI)

This gene has 1 transcript (splice variant), 95 orthologues and 7 paralogues.

Summary

This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, Hormones, and odorant and taste substances. This family member is classified as an Orphan Receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]

GPR174 Products (1)

mRNA Protein Name
NM_032553.3 NP_115942.1 probable G-protein coupled receptor 174

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
36823105 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of interleukin-2 production IDA
IDA: Inferred from direct assay
29457279 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR174 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (36 - 292)

  • 0
  • 100
  • 200
  • 300
  • 333 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 174

Related Diseases

Diseases Alias
Hypertensive Retinopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148608 LysoPalloT-NH-amide-C3-ph-m-O-C11 Agonist / Unkown
HY-RS05684 GPR174 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18864 Gpr174 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25356 Gpr174 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GPR174 RGD RGD:1564689
Bos taurus GPR174 VGNC VGNC:29571
Canis familiaris GPR174 VGNC VGNC:41417
Mus musculus GPR174 MGD MGI:2685222
Felis catus GPR174 VGNC VGNC:62688
Others GPR174 NCBI