RNASE7 - ribonuclease A family member 7 Gene

Also Known as RAE1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84659

About RNASE7

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,042,362-21,044,233 (from NCBI)

This gene has 2 transcripts (splice variants), 36 orthologues and 12 paralogues. Biased expression in esophagus (RPKM 35.9), skin (RPKM 11.5) and 1 other tissue.

Summary

The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

RNASE7 Products (1)

mRNA	Protein	Name
NM_032572.4	NP_115961.3	ribonuclease 7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA nuclease activity	IDA IDA: Inferred from direct assay	12244054	GOA
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	20180804	GOA
enables peptidoglycan binding	IDA IDA: Inferred from direct assay	20180804	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	25075772	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12244054	GOA
involved in cytolysis in another organism	IDA IDA: Inferred from direct assay	20180804	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	12244054	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	12244054	GOA
involved in defense response to fungus	IDA IDA: Inferred from direct assay	12244054	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	16940129	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25075772	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	19641608	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	25075772	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNASE7 Protein Structure

RnaseA

0
100
156 a.a.

Protein Preferred Names	Protein Names
ribonuclease 7	RNase 7

RNASE7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNASE7	Q9H1E1	RNH1	Homo sapiens	P13489	Anti Tag CoIP	28514442
Intra	RNASE7	Q9H1E1	RNH1	Homo sapiens	P13489	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Psoriasis
Superficial Mycosis	Piedra Steroid-Modified Tinea Infection
Pityriasis Versicolor	Tinea Versicolor Infection By Pityrosporum Furfur
Tinea Pedis	Athlete'S Foot Dermatophytosis Of Foot Ringworm Of Foot Moccasin Foot
Tinea Corporis	Dermatophytosis Of The Body Dermatophytosis Of The Trunk
Chronic Pyelonephritis
Acute Pyelonephritis	Apn - [Acute Pyelonephritis]
Dermatophytosis	Tinea Dermatophytosis, Unspecified Ringworm Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton Cutaneous Mycosis Dermal Mycosis Superficial Mycosis, Unspecified Fungus Infection Of Skin Skin Mycosis Dermatitis Fungoid Fungal Dermatitis Fungal Dermatosis Mycotic Infection Of Skin
Tinea Cruris	Dermatophytosis Of Groin & Perianal Area Dermatophytosis Of Groin And Perianal Area Dhobie Itch Tinea Of Perianal Region
Pyelitis
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12023	RNASE7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown