CHST1 - carbohydrate sulfotransferase 1 Gene

Also Known as C6ST; KSST; GST-1; KS6ST; KSGal6ST

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8534

About CHST1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:45,647,689-45,665,622 (from NCBI)

This gene has 3 transcripts (splice variants), 249 orthologues and 6 paralogues. Biased expression in brain (RPKM 12.8), thyroid (RPKM 2.7) and 6 other tissues.

Summary

This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]

CHST1 Products (1)

mRNA Protein Name
NM_003654.6 NP_003645.1 carbohydrate sulfotransferase 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables keratan sulfotransferase activity IDA
IDA: Inferred from direct assay
9405439 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sulfotransferase activity IDA
IDA: Inferred from direct assay
10330415 GOA
Biological Process GO Annotation Evidence Références Source
involved in galactose metabolic process IDA
IDA: Inferred from direct assay
10330415 GOA
involved in keratan sulfate biosynthetic process IDA
IDA: Inferred from direct assay
17690104 GOA
involved in keratan sulfate metabolic process IDA
IDA: Inferred from direct assay
9405439 GOA
involved in sulfur compound metabolic process IDA
IDA: Inferred from direct assay
10330415 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHST1 Protein Structure

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (60 - 384)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
Protein Preferred Names Protein Names

carbohydrate sulfotransferase 1

  • Keratan sulfotransferase

CHST1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
CHST1 O43916 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
CHST1 O43916 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
CHST1 O43916 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
CHST1 O43916 STOM Homo sapiens P27105
Validated Y2H
32296183
Intra
CHST1 O43916 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
CHST1 O43916 STOM Homo sapiens P27105
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Macular Dystrophy, Corneal

  • Macular Corneal Dystrophy

  • MCD

  • Corneal Dystrophy, Macular Type

  • Groenouw Type Ii Corneal Dystrophy

  • Fehr Corneal Dystrophy

  • Macular Dystrophy, Corneal Type 1

  • Mcdc1

  • Macular Corneal Dystrophy Type Ii

  • Macular Corneal Dystrophy, Type Ii

  • Macular Corneal Dystrophy, Type I

  • Mcdc1, Formerly

  • Macular Dystrophy, Corneal, 1

  • Macular Corneal Dystrophy Type 1

  • Corneal Dystrophy Groenouw Type Ii

  • Corneal Dystrophy Macular Type

  • Macular Corneal Dystrophy Type I

  • Dystrophy, Macular, Corneal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS02681 CHST1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19418 Chst1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25909 Chst1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CHST1 MGD MGI:1924219
Rattus norvegicus CHST1 RGD RGD:1308142
Macaca mulatta CHST1 VGNC VGNC:71055
Bos taurus CHST1 VGNC VGNC:27337
Canis familiaris CHST1 VGNC VGNC:39249
Felis catus CHST1 VGNC VGNC:81998
Others CHST1 NCBI